Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

Autor: Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, Nora Mühlegger, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo- and/or radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the mechanisms driving therapy-related leukemogenesis likely vary across di

Externí odkaz: https://doaj.org/article/133d1d021aba4ed18ed60a7266e30b7f

Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience

Autor: Judith M. Boer, Uri Ilan, Aurélie Boeree, Karin P. S. Langenberg, Jan Koster, Marco J. Koudijs, Jayne Y. Hehir‐Kwa, Stefan Nierkens, Corinne Rossi, Jan J. Molenaar, Bianca F. Goemans, Monique L. denBoer, C. Michel Zwaan

Publikováno v: HemaSphere, Vol 8, Iss 7, Pp n/a-n/a (2024)

Abstract Over the past 10 years, institutional and national molecular tumor boards have been implemented for relapsed or refractory pediatric cancer to prioritize targeted drugs for individualized treatment based on actionable oncogenic lesions, incl

Externí odkaz: https://doaj.org/article/cc8777c8974245468114f51e19691ae4

Outcome of children with relapsed acute myeloid leukemia improved over time in the Netherlands between 1998 and 2018

Autor: Jasper J. van de Pol, Maya Schulpen, Bianca F. Goemans, Gertjan Kaspers, Henrike E. Karim-Kos, C. Michel Zwaan

Publikováno v: EJC Paediatric Oncology, Vol 1, Iss , Pp 100010- (2023)

Background: Relapse is a major cause of treatment failure in children with acute myeloid leukemia (AML). The prognosis of children with relapsed AML is poor. Population-based data for this patient group are scarce. The aim of this study was to gain i

Externí odkaz: https://doaj.org/article/4026907871fa4c5a82a9f076f92630d8

Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia

Autor: Romy E. van Weelderen, Kim Klein, Christine J. Harrison, Yilin Jiang, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Riccardo Masetti, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C. Michel Zwaan, Gertjan J.L. Kaspers

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(16), 2963-2974. American Society of Clinical Oncology
van Weelderen, R E, Klein, K, Harrison, C J, Jiang, Y, Abrahamsson, J, Arad-Cohen, N, Bart-Delabesse, E, Buldini, B, de Moerloose, B, Dworzak, M N, Elitzur, S, Fernández Navarro, J M, Gerbing, R B, Goemans, B F, de Groot-Kruseman, H A, Guest, E, Ha, S-Y, Hasle, H, Kelaidi, C, Lapillonne, H L, Leverger, G, Locatelli, F, Masetti, R, Miyamura, T, Norén-Nyström, U, Polychronopoulou, S, Rasche, M, Rubnitz, J E, Stary, J, Tierens, A, Tomizawa, D, Zwaan, C M & Kaspers, G J L 2023, ' Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia : A Study by the International Berlin-Frankfurt-Münster Study Group ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 41, no. 16, pp. 2963-2974 . https://doi.org/10.1200/JCO.22.02120
JOURNAL OF CLINICAL ONCOLOGY

PURPOSE A previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood KMT2A-rearranged ( KMT2A-r) AML demonstrated the prognostic value of the fusion partner. This I-BFM-SG study investigated the value of flow cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccda2bbe5c51ff6074f87e156c5eb4a
http://www.scopus.com/inward/record.url?scp=85160455151&partnerID=8YFLogxK

Data from Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms

Autor: Ruben van Boxtel, Bianca F. Goemans, C. Michel Zwaan, Hester A. de Groot-Kruseman, Markus J. van Roosmalen, Rurika Oka, Marry M. van den Heuvel-Eibrink, Mark Verheul, Anaïs J.C.N. van Leeuwen, Arianne M. Brandsma, Jurrian K. de Kanter, Axel K.M. Rosendahl Huber, Eline J.M. Bertrums

Childhood cancer survivors are confronted with various chronic health conditions like therapy-related malignancies. However, it is unclear how exposure to chemotherapy contributes to the mutation burden and clonal composition of healthy tissues early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f08e9ef66548e287e4204011bb36a9a
https://doi.org/10.1158/2159-8290.c.6549550