Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome

Autor: Livia Cosentino, Chiara Urbinati, Chiara Lanzillotta, Domenico De Rasmo, Daniela Valenti, Mattia Pellas, Maria Cristina Quattrini, Fabiana Piscitelli, Magdalena Kostrzewa, Fabio Di Domenico, Donatella Pietraforte, Tiziana Bisogno, Anna Signorile, Rosa Anna Vacca, Bianca De Filippis

Publikováno v: Molecular Autism, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Background Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett syndrome (RTT), a rare neurologic disorder that severely affects mainly fem

Externí odkaz: https://doaj.org/article/8f0a63e3f3f04232b7cd24a12f9c6f55

Unravelling large-scale patterns and drivers of biodiversity in dry rivers

Autor: Arnaud Foulquier, Thibault Datry, Roland Corti, Daniel von Schiller, Klement Tockner, Rachel Stubbington, Mark O. Gessner, Frédéric Boyer, Marc Ohlmann, Wilfried Thuiller, Delphine Rioux, Christian Miquel, Ricardo Albariño, Daniel C. Allen, Florian Altermatt, Maria Isabel Arce, Shai Arnon, Damien Banas, Andy Banegas-Medina, Erin Beller, Melanie L. Blanchette, Joanna Blessing, Iola Gonçalves Boëchat, Kate Boersma, Michael Bogan, Núria Bonada, Nick Bond, Katherine Brintrup, Andreas Bruder, Ryan Burrows, Tommaso Cancellario, Cristina Canhoto, Stephanie Carlson, Núria Cid, Julien Cornut, Michael Danger, Bianca de Freitas Terra, Anna Maria De Girolamo, Rubén del Campo, Verónica Díaz Villanueva, Fiona Dyer, Arturo Elosegi, Catherine Febria, Ricardo Figueroa Jara, Brian Four, Sarig Gafny, Rosa Gómez, Lluís Gómez-Gener, Simone Guareschi, Björn Gücker, Jason Hwan, J. Iwan Jones, Patrick S. Kubheka, Alex Laini, Simone Daniela Langhans, Bertrand Launay, Guillaume Le Goff, Catherine Leigh, Chelsea Little, Stefan Lorenz, Jonathan Marshall, Eduardo J. Martin Sanz, Angus McIntosh, Clara Mendoza-Lera, Elisabeth I. Meyer, Marko Miliša, Musa C. Mlambo, Manuela Morais, Nabor Moya, Peter Negus, Dev Niyogi, Iluminada Pagán, Athina Papatheodoulou, Giuseppe Pappagallo, Isabel Pardo, Petr Pařil, Steffen U. Pauls, Marek Polášek, Pablo Rodríguez-Lozano, Robert J. Rolls, Maria Mar Sánchez-Montoya, Ana Savić, Oleksandra Shumilova, Kandikere R. Sridhar, Alisha Steward, Amina Taleb, Avi Uzan, Yefrin Valladares, Ross Vander Vorste, Nathan J. Waltham, Dominik H. Zak, Annamaria Zoppini

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract More than half of the world’s rivers dry up periodically, but our understanding of the biological communities in dry riverbeds remains limited. Specifically, the roles of dispersal, environmental filtering and biotic interactions in drivin

Externí odkaz: https://doaj.org/article/aa0ba8794bf74e0daff98fc2a5abbcc7

Health and education needs of primary school children with Down Syndrome in England: What can we learn from linked administrative data?

Autor: Julia Shumway, Ruth Gilbert, Bianca De Stavola, Ania Zylbersztejn

Publikováno v: International Journal of Population Data Science, Vol 9, Iss 5 (2024)

Objective Children with Down syndrome (DS) have high rates of chronic health conditions (CHCs) which can affect special education needs and primary school placement (mainstream or special). We assessed timing and type of CHC by year-specific primary

Externí odkaz: https://doaj.org/article/bc21b526ef314fdd8d47bc27b2030917

Local authority variation in special educational needs provision at the start of primary school: observational study of preterm children born in England, 2003-2013

Autor: Kate Lewis, Vincent Nguyen, Bianca De Stavola, Lorraine Dearden

Publikováno v: International Journal of Population Data Science, Vol 9, Iss 5 (2024)

Objective and Approach We explored variation in special educational needs (SEN) provision between local authorities (LAs) in England by focussing on children born preterm (24-

Externí odkaz: https://doaj.org/article/a24afcd334894384b05e53ec79f8d98f

A neighborhood search-based heuristic for the dynamic vehicle routing problem

Autor: Wilton Gustavo Gomes da Costa, Ricardo Santos, Willy Alves de Oliveira Soler, Bianca de Almeida Dantas

Publikováno v: Revista Principia, Vol 62, Iss 0 (2025)

The Vehicle Routing Problem (VRP) is a classical optimization problem that aims to find routes for a fleet of vehicles to meet the demands of a set of customers. Due to its wide applicability, especially in the logistics sector, numerous VRP variants

Externí odkaz: https://doaj.org/article/47d1df53330441808983751f3b650e16