Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration

Autor: Bianca Cioni, Ekaterina Nevedomskaya, Monique H. M. Melis, Johan vanBurgsteden, Suzan Stelloo, Emma Hodel, Daniele Spinozzi, Jeroen deJong, Henk vander Poel, Jan Paul deBoer, Lodewyk F. A. Wessels, Wilbert Zwart, Andries M. Bergman

Publikováno v: Molecular Oncology, Vol 12, Iss 8, Pp 1308-1323 (2018)

Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa

Externí odkaz: https://doaj.org/article/2fbada9ef3c642f4ad347138544195c4

Data from JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer

Autor: Mario P. Colombo, Daniele Lecis, Claudia Chiodoni, Loris De Cecco, Laura Botti, Tiziana Langella, Francesca Menichetti, Matteo Milani, Irene Tripodi, Annamaria Piva, Silvia Ratti, Bianca Cioni

Breast cancer is the most common type of cancer in women worldwide, with the luminal subtype being the most widespread. Although characterized by better prognosis compared with other subtypes, luminal breast cancer is still considered a threatening d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e211b83b18722fdb4a3d89cd33c383
https://doi.org/10.1158/1541-7786.c.6491038

Figure S2 from JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer

Autor: Mario P. Colombo, Daniele Lecis, Claudia Chiodoni, Loris De Cecco, Laura Botti, Tiziana Langella, Francesca Menichetti, Matteo Milani, Irene Tripodi, Annamaria Piva, Silvia Ratti, Bianca Cioni

JMJD6 regulates lipid metabolism in MCF7 cells. A) Immunohistochemistry staining for ANXA1 (brown) combined with Oil red-O staining (pink) for lipid droplets visualization in wild-type MCF7 cells B) Gene set enrichment plot for 'Hallmark of Adipogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d62b8aa0499b4f682cc5d1fe97ea58
https://doi.org/10.1158/1541-7786.22551406.v1

Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Autor: Judy R. van Beijnum, Jan de Boer, Monique H.M Melis, Yoni Lubeck, Anniek Zaalberg, Mauro J. Muraro, Ingrid Hofland, Joyce Sanders, Andries M. Bergman, Erik Hooijberg, Bianca Cioni, Arjan W. Griffioen, Henk G. van der Poel, Jeroen de Jong, Wilbert Zwart, Johan van Burgsteden, Judith Vivié, Dennis Peters

Publikováno v: Nature Communications, 11(1):4498. Nature Publishing Group UK
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Cioni, B, Zaalberg, A, van Beijnum, J R, Melis, M H M, van Burgsteden, J, Muraro, M J, Hooijberg, E, Peters, D, Hofland, I, Lubeck, Y, de Jong, J, Sanders, J, Vivié, J, van der Poel, H G, de Boer, J P, Griffioen, A W, Zwart, W & Bergman, A M 2020, ' Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion ', Nature Communications, vol. 11, no. 1, 4498, pp. 4498 . https://doi.org/10.1038/s41467-020-18313-y
Nature Communications, 11(1):4498. Nature Publishing Group

The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7992137e6362d104fb4e2fda68436a
https://research.vumc.nl/en/publications/442a9c5a-96f4-4acc-84bf-d17a819ef7a8

HLA class II expression on tumor cells and low numbers of tumor‐associated macrophages predict clinical outcome in oropharyngeal cancer

Autor: Jan de Boer, Charlotte L. Zuur, Annegien Broeks, Joris B. W. Elbers, Erik Hooijberg, Stefan M. Willems, Katherine Tan, Ekaterina S. Jordanova, Andries M. Bergman, Renee X. de Menezes, Bianca Cioni, Rianne van der Linden

Publikováno v: Head & Neck
Head and Neck, 41(2), 463-478. Wiley Subscription Services, Inc., A Wiley Company Hoboken
Cioni, B, Jordanova, E S, Hooijberg, E, van der Linden, R, de Menezes, R X, Tan, K, Willems, S, Elbers, J B W, Broeks, A, Bergman, A M, Zuur, C L & de Boer, J P 2019, ' HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer ', Head and Neck, vol. 41, no. 2, pp. 463-478 . https://doi.org/10.1002/hed.25442

Background Human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV‐positive OPSCC patient. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de041a2541fe5949709c1aa478046cd9
https://doi.org/10.1002/hed.25442