Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Bianca, Nitzsche"'
Autor:
Bianca Nitzsche, Michael Höpfner
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/a879b9b4bc9e4ddfa1214e43416dd586
Autor:
Gustav Steinemann, Alexandra Dittmer, Jacob Schmidt, David Josuttis, Michael Fähling, Bernhard Biersack, Nicola Beindorff, Eva Jolante Koziolek, Rainer Schobert, Winfried Brenner, Thomas Müller, Bianca Nitzsche, Michael Höpfner
Publikováno v:
Molecular Oncology, Vol 13, Iss 12, Pp 2679-2696 (2019)
Chimeric inhibitors, which merge two drug pharmacophores in a single molecule have become a prominent approach for the design of novel anticancer compounds. Here, we examined animacroxam, which combines histone deacetylase (HDAC) inhibitory and cytos
Externí odkaz:
https://doaj.org/article/d0a6a347bd194f60846e39f66281417c
Autor:
Nils Goehringer, Yayi Peng, Bianca Nitzsche, Hannah Biermann, Rohan Pradhan, Rainer Schobert, Marco Herling, Michael Höpfner, Bernhard Biersack
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1319 (2021)
The development of new anticancer drugs is necessary in order deal with the disease and with the drawbacks of currently applied drugs. Epigenetic dysregulations are a central hallmark of cancerogenesis and histone deacetylases (HDACs) emerged as prom
Externí odkaz:
https://doaj.org/article/368026ab9c6c4248b0734b1f915067ac
Autor:
Niklas Hegemann, Willem Bintig, Paul-Lennard Perret, Judith Rees, Alessandra Viperino, Britta Eickholt, Wolfgang M. Kuebler, Michael Höpfner, Bianca Nitzsche, Jana Grune
Publikováno v:
Basic Research in Cardiology. 118
Preclinical cardiovascular research relies heavily on non-invasive in-vivo echocardiography in mice and rats to assess cardiac function and morphology, since the complex interaction of heart, circulation, and peripheral organs are challenging to mimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5597e489166d4bbd21d6ca5aa4047446
https://doi.org/10.1007/s00395-023-00989-0
https://doi.org/10.1007/s00395-023-00989-0
Autor:
Natalie Oberhuber, Hindole Ghosh, Bianca Nitzsche, Prasad Dandawate, Michael Höpfner, Rainer Schobert, Bernhard Biersack
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 854
New N-alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their (p-cymene)Ru(II) piano-stool complexes were prepared and tested for their antiproliferative efficacy in various cancer models. Some of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38790beb0534f45dc96fcc0a975ee08
Autor:
Natalie, Oberhuber, Hindole, Ghosh, Bianca, Nitzsche, Prasad, Dandawate, Michael, Höpfner, Rainer, Schobert, Bernhard, Biersack
Publikováno v:
International journal of molecular sciences. 24(1)
New
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62b0933d61ca287ee6c215ea31b034e9
https://pubmed.ncbi.nlm.nih.gov/36614289
https://pubmed.ncbi.nlm.nih.gov/36614289
Publikováno v:
Seminars in celldevelopmental biology.
Histone deacetylases (HDACs) are promising targets for the design of anticancer drugs. HDAC6 is of particular interest since it is a cytoplasmic HDAC regulating the acetylation state of cancer-relevant cytoplasmic proteins such as tubulin, Hsp90, p53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f689af98bc83720f8eb248b4983e5085
https://pubmed.ncbi.nlm.nih.gov/36127263
https://pubmed.ncbi.nlm.nih.gov/36127263
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 5; Pages: 738
New medical treatments are urgently needed for advanced hepatocellular carcinoma (HCC). Recently, we showed the anticancer effects of novel thiophene-based kinase inhibitors. In this study, we further characterized the antineoplastic effects and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::2eca69255b65f7924bf02738cd07137b
New medical treatments are urgently needed for advanced hepatocellular carcinoma (HCC). Recently, we showed the anticancer effects of novel thiophene-based kinase inhibitors. In this study, we further characterized the antineoplastic effects and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fe48f207d1cf8540cf9fa70b455411
Publikováno v:
Cancer Drug Resistance.
Epigenetic mechanisms play an important role in the development and persistence of cancer, and histone deacetylase (HDAC) inhibitors are promising anticancer drugs targeting epigenetic modes. Efficient anticancer drugs for the treatment of castration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade6a4a9fdb9a78bf9d6f548bb8c4593
https://doi.org/10.20517/cdr.2021.105
https://doi.org/10.20517/cdr.2021.105