Zobrazeno 1 - 10
of 1 414
pro vyhledávání: '"Bian Li"'
Autor:
Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Zerubabell A. Daniel, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background KCNE1 encodes a 129-residue cardiac potassium channel (I Ks) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most variants have insufficient evidence of clinical consequences and thus
Externí odkaz:
https://doaj.org/article/b05f643c1f884a7dbcf19bfac871b67b
Publikováno v:
Applied Mathematics and Nonlinear Sciences, Vol 8, Iss 2, Pp 1433-1446 (2023)
With the rapid development of China’s electric power industry, the cost management of electric power projects, which is closely related to the power grid transmission and substation projects, has become more and more important. Do a good investment
Externí odkaz:
https://doaj.org/article/67d23110dbb843d6bebc140ad3c90905
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Objective To investigate the perinatal and in-hospital risk factors associated with the high incidence of amblyopia in preterm infants and to analyze the correlation between the amblyopia and neurodevelopment. Methods Children discharged fro
Externí odkaz:
https://doaj.org/article/a1ca2d90f9ff40a4bb4458981d2440d0
Publikováno v:
Molecules, Vol 28, Iss 22, p 7565 (2023)
Apigenin (API) possesses excellent antitumor properties but its limited water solubility and low bioavailability restrict its therapeutic impact. Thus, a suitable delivery system is needed to overcome these limitations and improve the therapeutic eff
Externí odkaz:
https://doaj.org/article/028b14c2194f440685965de66f2d9921
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Li et al. integrate population genetic and protein structural perspectives to map the landscape of 3D constraint on 80% of human proteins. They show that 3D mutational constraint is pervasive and strongly associated with functional relevance.
Externí odkaz:
https://doaj.org/article/282470f661be457889eb3cd0f5af2e74
Autor:
Gan-Xiao Chen, Hector Barajas-Martínez, Giuseppe Ciconte, Cheng-I Wu, Michelle M. Monasky, Hao Xia, Bian Li, John A. Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H. Gollob, Charles Antzelevitch, Arthur A.M. Wilde, Carlo Pappone, Dan Hu
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104388- (2023)
Summary: Background: Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever. Methods: A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including 198 (75.9%) and 27
Externí odkaz:
https://doaj.org/article/d15cdf54f8b04193a86c33c050c93e71
Autor:
Souhrid Mukherjee, Thomas A. Cassini, Ningning Hu, Tao Yang, Bian Li, Wangzhen Shen, Christopher W. Moth, David C. Rinker, Jonathan H. Sheehan, Joy D. Cogan, John H. Newman, Rizwan Hamid, Robert L. Macdonald, Dan M. Roden, Jens Meiler, Georg Kuenze, John A. Phillips, John A. Capra
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100131- (2022)
Summary: Whole-exome sequencing (WES) in the clinic has identified several rare monogenic developmental and epileptic encephalopathies (DEE) caused by ion channel variants. However, WES often fails to provide actionable insight for rare diseases, suc
Externí odkaz:
https://doaj.org/article/80f15d97adae43d6b743ecd6b1a9570f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 699-711 (2019)
Protein-protein interaction (PPI) is an essential mechanism by which proteins perform their biological functions. For globular proteins, the molecular characteristics of such interactions have been well analyzed, and many computational tools are avai
Externí odkaz:
https://doaj.org/article/ab2edc1e167f41d2854ce4d55b211e79
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008291 (2020)
Predicting mutation-induced changes in protein thermodynamic stability (ΔΔG) is of great interest in protein engineering, variant interpretation, and protein biophysics. We introduce ThermoNet, a deep, 3D-convolutional neural network (3D-CNN) desig
Externí odkaz:
https://doaj.org/article/5bb0466abe384ab3baa2cbc0c6d95c3d
Autor:
Samantha M. Y. Chen, Bian Li, Andrew G. Nicklawsky, Alexandra L. Krinsky, Tonya Brunetti, Rachel A. Woolaver, Xiaoguang Wang, Zhangguo Chen, Christian D. Young, Dexiang Gao, Xiao-Jing Wang, Jing H. Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6585 (2020)
Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,
Externí odkaz:
https://doaj.org/article/4d124c635f42414b9c9635b0fecf3074