Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

Autor: Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Science

Visual Abstract
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca6171c32bb98e41fff95ae5384ca4
http://www.sciencedirect.com/science/article/pii/S2452302X19301822

Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia

Autor: Mieke Metzemaekers, Susan M. Schlenner, Emanuela Pasciuto, Patrick Matthys, Stephanie Humblet-Baron, Elien Smeets, Adrian Liston, Axelle Kerstens, Joost Schymkowitz, Laura Seldeslachts, Paul Proost, Sarah Haßdenteufel, Carine Wouters, Frank Claessens, Julika Neumann, Teresa Prezzemolo, Nancy Boeckx, Vasiliki Lagou, John S. Barber, Frederic Rousseau, Bert Malengier-Devlies, Rob van der Kant, Erika Van Nieuwenhove, Christine Devalck, Isabelle Meyts, Sven Lang, Richard Zimmermann, Daniele Di Marino, Sebastian Munck, Mathijs Willemsen

Publikováno v: Journal of allergy and clinical immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology

Background: The molecular cause of severe congenital neutropenia (SCN) is unknown in 30% to 50% of patients. SEC61A1 encodes the α-subunit of the Sec61 complex, which governs endoplasmic reticulum protein transport and passive calcium leakage. Recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4167ed5c5db874f50ba44ce06bf3f6
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/307196

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Autor: Natalia Shpiro, Maria Stella Ritorto, Kei Sakamoto, Dario R. Alessi, Vanessa P. Houde, Robert Gourlay, Joby Varghese, Paul Davies

Publikováno v: Biochemical Journal

The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe36ddd49d60988f3b36857bd507191
https://doi.org/10.1042/bj20131324

The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells

Autor: Xiaoling Zheng, Jie Li, Yuling He, Wei Huang, Changxuan Liu, Zhiqing Tang, Li Yan, Li Wang, Guoguo Zhu, Lang Chen, Ru Yang, Li Li, Jinquan Tan, Ruijing Xiao

Publikováno v: Bioscience Reports

The ability of human cells to defend against viruses originating from distant species has long been ignored. Owing to the pressure of natural evolution and human exploration, some of these viruses may be able to invade human beings. If their ‘fresh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13bb975f39884f0375c3a515cc690a9
https://doi.org/10.1042/bsr20110069

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

Autor: Cecilie L. Søltoft, Christian Appenzeller-Herzog, Jonas D. Schmidt, Julia Birk, Henning Gram Hansen, Lars Ellgaard

Publikováno v: Bioscience reports
Bioscience Reports, Vol 34, Iss 2, p e00103 (2014)
Hansen, H G, Søltoft, C L, Schmidt, J D, Birk, J, Appenzeller-Herzog, C & Ellgaard, L 2014, ' Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262 ', Bioscience Reports, vol. 34, no. 2 . https://doi.org/10.1042/BSR20130124
Bioscience Reports

In the ER (endoplasmic reticulum) of human cells, disulfide bonds are predominantly generated by the two isoforms of Ero1 (ER oxidoreductin-1): Ero1α and Ero1β. The activity of Ero1α is tightly regulated through the formation of intramolecular dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75841a7dd7e7dc7c58d4a07ccc9ba5a
https://doi.org/10.1042/bsr20130124