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The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease

Autor: Song, Yongli, Guerrero-Juarez, Christian F, Chen, Zhongjian, Tang, Yichen, Ma, Xianghui, Lv, Cong, Bi, Xueyun, Deng, Min, Bu, Lina, Tian, Yuhua, Liu, Ruiqi, Zhao, Ran, Xu, Jiuzhi, Sheng, Xiaole, Du, Sujuan, Liu, Yeqiang, Zhu, Yunlu, Shan, Shi-Jun, Chen, Hong-Duo, Zhao, Yiqiang, Zhou, Guangbiao, Shuai, Jianwei, Ren, Fazheng, Xue, Lixiang, Ying, Zhaoxia, Dai, Xing, Lengner, Christopher J, Andersen, Bogi, Plikus, Maksim V, Nie, Qing, Yu, Zhengquan

Publikováno v: Cell research, vol 30, iss 10

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1974444bd7b6f8bfc6013f48f23709bc
https://escholarship.org/uc/item/4kd1d4zd

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The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.

Autor: Song Y; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.; College of Animal Science and Technology, Jilin Agricultural Science and Technology College, Changchun, Jilin, 100132, China., Guerrero-Juarez CF; Department of Mathematics, NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, CA, 92697, USA.; Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research, Center for Complex Biological Systems, University of California, Irvine, CA, 92697, USA., Chen Z; Shanghai Skin Disease Hospital, Shanghai, 200443, China., Tang Y; Shanghai Skin Disease Hospital, Shanghai, 200443, China., Ma X; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Lv C; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Bi X; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Deng M; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Bu L; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Tian Y; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Liu R; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Zhao R; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Xu J; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Sheng X; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Du S; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Liu Y; Shanghai Skin Disease Hospital, Shanghai, 200443, China., Zhu Y; Shanghai Skin Disease Hospital, Shanghai, 200443, China., Shan SJ; Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, China., Chen HD; Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning, 110001, China., Zhao Y; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China., Zhou G; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Shuai J; Department of Physics and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, Fujian, 361005, China., Ren F; Beijing Advanced Innovation Center for Food Nutrition and Human Health and, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, 100193, China., Xue L; Medical Research Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing, 100191, China., Ying Z; The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China., Dai X; Departments of Biological Chemistry and Dermatology, School of Medicine, University of California, Irvine, CA, 92697, USA., Lengner CJ; Department of Animal Biology, School of Veterinary Medicine, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19082, USA., Andersen B; Departments of Medicine and Biological Chemistry, University of California, Irvine, CA, 92697, USA., Plikus MV; Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research, Center for Complex Biological Systems, University of California, Irvine, CA, 92697, USA., Nie Q; Department of Mathematics, NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, CA, 92697, USA.; Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research, Center for Complex Biological Systems, University of California, Irvine, CA, 92697, USA., Yu Z; State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. zyu@cau.edu.cn.

Publikováno v: Cell research [Cell Res] 2020 Oct; Vol. 30 (10), pp. 854-872. Date of Electronic Publication: 2020 May 26.