Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Bhuvaneswari Sakthivel"'
1
Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock
Autor: Meena Kalyanaraman, Neal J. Thomas, Scott Penfil, Hector R. Wong, Natalie Z. Cvijanovich, Richard Lin, Bruce J. Aronow, Nancy M. Tofil, Michael R. Barnes, Marie Monaco, Thomas P. Shanley, Allan Doctor, Kelli Odoms, Geoffrey L. Allen, Bhuvaneswari Sakthivel
Publikováno v: Molecular Medicine. 13:495-508
We have conducted longitudinal studies focused on the expression profiles of signaling pathways and gene networks in children with septic shock. Genome-level expression profiles were generated from whole blood-derived RNA of children with septic shoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83e53e5a340cda1c22c7bc2f4c4241e
https://doi.org/10.2119/2007-00065.shanley
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2
Environmental impact on direct neuronal reprogramming in vivo in the adult brain
Autor: Kenneth Campbell, Andrew W. Grande, Bhuvaneswari Sakthivel, Masato Nakafuku, Kyoko Sumiyoshi, Bruce J. Aronow, Jennifer Howard, Alejandro López-Juárez
Publikováno v: Nature communications
Direct reprogramming of non-neuronal cells to generate new neurons is a promising approach to repair damaged brains. Impact of the in vivo environment on neuronal reprogramming, however, is poorly understood. Here we show that regional differences an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdf3dcb7ad268bde970cda17d5b3cbf
https://doi.org/10.1038/ncomms3373
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3
Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model
Autor: Bhuvaneswari Sakthivel, Dean Y. Li, Varun K. Krishnamurthy, Robert B. Hinton, Daria A. Narmoneva, Jennifer Adelman-Brown, Robert P. Mecham, Hanna Osinska, D. Woodrow Benson, Sandra A. Witt, Jeanne James
Publikováno v: Circulation research. 107(4)
Rationale: Elastin is a ubiquitous extracellular matrix protein that is highly organized in heart valves and arteries. Because elastic fiber abnormalities are a central feature of degenerative valve disease, we hypothesized that elastin-insufficient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0a8b6bc15f1d376a5dd3317bbac21c
https://pubmed.ncbi.nlm.nih.gov/20576933
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4
Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum
Autor: Thomas P. Shanley, Richard Lin, Geoffrey L. Allen, Robert J. Freishtat, Kelli Odoms, Bhuvaneswari Sakthivel, Nick Anas, Marie Monaco, Hector R. Wong, Keith Meyer, Natalie Z. Cvijanovich
The systemic inflammatory response syndrome (SIRS) is common in critically ill children (1). SIRS is not a specific disease and recognition of SIRS does not necessarily drive clinical decision processes (2). SIRS is defined by alterations of three fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba75f2b8a2f251b95e08b7db86738d1
https://europepmc.org/articles/PMC2747356/
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5
Shared gene expression profiles in developing heart valves and osteoblast progenitor cells
Autor: Santanu Chakraborty, Bhuvaneswari Sakthivel, Bruce J. Aronow, Jonathan D. Cheek, Katherine E. Yutzey
Publikováno v: Physiological genomics. 35(1)
The atrioventricular (AV) valves of the heart develop from undifferentiated mesenchymal endocardial cushions, which later mature into stratified valves with diversified extracellular matrix (ECM). Because the mature valves express genes associated wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91af1b7de5abff39b1e24af71bdc0094
https://pubmed.ncbi.nlm.nih.gov/18612084
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6
VALIDATING THE GENOMIC SIGNATURE OF PEDIATRIC SEPTIC SHOCK
Autor: Robert J. Freishtat, Kelli Odoms, Hector R. Wong, Marie Monaco, Natalie Z. Cvijanovich, Thomas P. Shanley, Richard Lin, Bhuvaneswari Sakthivel, Neal J. Thomas, Nick Anas, Paul A. Checchia, Geoffrey L. Allen
We previously generated genome-wide expression data (microarray) from children with septic shock having the potential to lead the field into novel areas of investigation. Herein we seek to validate our data through a bioinformatic approach centered o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f103f94855b17d0214d936c1ddb357d
https://europepmc.org/articles/PMC2440641/
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7
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome
Autor: Richard Lin, Meena Kalyanaraman, Katherine E. Dunsmore, Mary Ann Tagavilla, Hector R. Wong, Scott Penfil, Bruce J. Aronow, Marie Monaco, Natalie Z. Cvijanovich, Thomas P. Shanley, Kelli Odoms, Allan Doctor, Neal J. Thomas, Bhuvaneswari Sakthivel, Geoffrey L. Allen, Michael R. Barnes, Nancy M. Tofil
Publikováno v: Physiological genomics. 30(2)
Human septic shock involves multiple genome-level perturbations. We have conducted microarray analyses in children with septic shock within 24 h of intensive care unit admission, using whole blood-derived RNA. Based on sequential statistical and expr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc83c95c6a543432e9937322950918dd
https://pubmed.ncbi.nlm.nih.gov/17374846
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