Výsledky vyhledávání - "Bhuvanesh Dave"

Akademický článek

Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Autor: Roberto R. Rosato, Daniel Dávila-González, Dong Soon Choi, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave, Jenny C. Chang

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)

Abstract Background Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined the in vivo activity o

Externí odkaz: https://doaj.org/article/82c3a593740f453a94431feea13df07e

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Akademický článek

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway

Publikováno v: Stem Cell Reports, Vol 10, Iss 1, Pp 212-227 (2018)

Summary: Here, we show that HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED 1-LIKE (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free sur

Externí odkaz: https://doaj.org/article/6ac0ef8b61ff4c0b9ea6f3ce7f576e2a

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Akademický článek

Design and in vitro evaluation of layer by layer siRNA nanovectors targeting breast tumor initiating cells.

Autor: Hamsa Jaganathan, Sucharita Mitra, Srimeenakshi Srinivasan, Bhuvanesh Dave, Biana Godin

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e91986 (2014)

Efficient therapeutics and early detection has helped to increase breast cancer survival rates over the years. However, the recurrence of breast cancer remains to be a problem and this may be due to the presence of a small population of cells, called

Externí odkaz: https://doaj.org/article/8b86a8c228e740219f7b7f5de5c7225e

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Akademický článek

Correction: Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model.

Autor: Bhuvanesh Dave, Melissa D. Landis, Lacey E. Dobrolecki, Meng-Fen Wu, Xiaomei Zhang, Thomas F. Westbrook, Susan G. Hilsenbeck, Dan Liu, Michael T. Lewis, David J. Tweardy, Jenny C. Chang

Publikováno v: PLoS ONE, Vol 7, Iss 9 (2012)

Externí odkaz: https://doaj.org/article/7a6c65afc0ae4cb397a3bc3ab093a1c6

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Akademický článek

Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model.

Autor: Bhuvanesh Dave, Melissa D Landis, David J Tweardy, Jenny C Chang, Lacey E Dobrolecki, Meng-Fen Wu, Xiaomei Zhang, Thomas F Westbrook, Susan G Hilsenbeck, Dan Liu, Michael T Lewis

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e30207 (2012)

Metastasis and disease relapse are hypothesized to result from tumor initiating cells (TICs). Previously, we have defined a CD44+/CD24-/low mammosphere-forming tumorigenic 493-gene signature in breast cancer. Stat3 was identified as a critical node i

Externí odkaz: https://doaj.org/article/fdd96bf9adac4b59864da87f5c9bf9f7

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