Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

Autor: Mead TJ; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA. Electronic address: tjm192@case.edu., Bhutada S; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Foulcer SJ; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Peruzzi N; Department of Experimental Medical Science, and Wallenberg Center for Molecular Medicine Lund University and The Pediatric Heart Center, Skane University Hospital, Lund, Sweden., Nelson CM; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Seifert DE; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Larkin J; SynOA Therapeutics, Philadelphia, PA 19119, USA., Tran-Lundmark K; Department of Experimental Medical Science, and Wallenberg Center for Molecular Medicine Lund University and The Pediatric Heart Center, Skane University Hospital, Lund, Sweden., Filmus J; Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Apte SS; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. Electronic address: aptes@ccf.org.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2024 Aug; Vol. 131, pp. 1-16. Date of Electronic Publication: 2024 May 13.

Stress, resilience, and coping in COVID-19 patients and non-COVID-19 people.

Autor: Kakulte A; Department of Psychology, Sir Parashurambhau College, Pune, Maharashtra, India., Bhutada S; Department of Psychology, Sir Parashurambhau College, Pune, Maharashtra, India.

Publikováno v: Industrial psychiatry journal [Ind Psychiatry J] 2023 Nov; Vol. 32 (Suppl 1), pp. S250-S252. Date of Electronic Publication: 2023 Nov 30.

Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

Autor: DeAngelo Lp, Suneel S. Apte, Ziolo Mt, Tallquist, Bhutada S, Gojanovich Gs, Shettigar, Heckl, Johansooz, Tacdol Dk, Kuwabara Jt

Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebd2f86145f6865f156b9b6fe5fc0963
https://doi.org/10.1101/2021.05.07.443103

Consequences of PDGFRα ⁺ fibroblast reduction in adult murine hearts.

Autor: Kuwabara JT; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States.; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Hara A; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Bhutada S; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, United States., Gojanovich GS; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Chen J; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States.; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Hokutan K; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Shettigar V; Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, United States., Lee AY; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., DeAngelo LP; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Heckl JR; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States.; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Jahansooz JR; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Tacdol DK; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States., Ziolo MT; Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, United States., Apte SS; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, United States., Tallquist MD; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, United States.

Publikováno v: ELife [Elife] 2022 Sep 23; Vol. 11. Date of Electronic Publication: 2022 Sep 23.

Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation.

Autor: Kuwabara JT; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Hara A; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Heckl JR; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Peña B; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America., Bhutada S; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, United States of America., DeMaris R; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Ivey MJ; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267, United States of America., DeAngelo LP; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Liu X; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Park J; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Jahansooz JR; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America., Mestroni L; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America., McKinsey TA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America., Apte SS; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, United States of America., Tallquist MD; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States of America. Electronic address: michelle.tallquist@hawaii.edu.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2022 Aug; Vol. 169, pp. 84-95. Date of Electronic Publication: 2022 May 13.