Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Bhupendra P. Doctor"'
Publikováno v:
Chemico-Biological Interactions. 203:120-124
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (
Autor:
Madhusoodana P. Nambiar, Ying Wang, Alan P. Kozikowski, Hendra Gunosewoyo, Suresh K. Tipparaju, Marco Pieroni, Bhupendra P. Doctor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1544-1547
Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (-)-huperzine A is
Publikováno v:
Chemico-Biological Interactions. 203:172-176
Exogenously administered human serum butyrylcholinesterase (Hu BChE) was demonstrated to function as a bioscavenger of highly toxic organophosphorus (OP) compounds in several animal species. Since the enzyme is isolated from human serum, it is curren
Autor:
Ashima Saxena, Kunjan A. Patel, Bhupendra P. Doctor, Nagarajan Pattabiraman, Ramachandra S. Naik
Publikováno v:
Chemico-Biological Interactions. 203:24-29
Human serum butyrylcholinesterase (HuBChE) is currently the most suitable bioscavenger for the prophylaxis of highly toxic organophosphate (OP) nerve agents. A dose of 200mg of HuBChE is envisioned as a prophylactic treatment that can protect humans
Publikováno v:
Journal of Controlled Release. 160:217-224
We formulated a new gene delivery system based on targeted liposomes. The efficacy of the delivery system was demonstrated in in vitro and in vivo models. The targeting moiety consists of a high-affinity 7-amino-acid peptide, covalently and evenly co
Autor:
Ashima Saxena, Todd M. Myers, Wei Sun, Matthew G. Clark, Ramachandra S. Naik, Bhupendra P. Doctor
Publikováno v:
Neurotoxicology and Teratology. 34:323-330
The effects of a large dose of human serum butyrylcholinesterase (HuBChE) were evaluated in rhesus monkeys using a serial-probe recognition (SPR) task designed to assess attention and short-term memory. Each monkey received an intravenous injection o
Publikováno v:
Toxicology Letters. 210:87-94
Human paraoxonase 1 (PON1), a 45 kDa arylesterase associated with circulating high density lipoproteins (HDL), has been described as an anti-atherogenic element in cardiovascular disorders. The efficacy of PON1 as a catalytic bioscavenger against OP
Autor:
Lionel Biggemann, Manojkumar Valiyaveettil, Radley Short, Iswarduth Soojhawon, Madhusoodana P. Nambiar, Savita V. Nigam, Michael Costante, Gregory E. Garcia, Yonas Alamneh, Bhupendra P. Doctor
Publikováno v:
Toxicology in Vitro. 26:182-188
Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bios
Autor:
Madhusoodana P. Nambiar, Prashasthi Agrawal, Iswarduth Soojhawon, Manojkumar Valiyaveettil, Heba A. Farag, Lionel Biggemann, Bhupendra P. Doctor, Yonas Alamneh
Publikováno v:
Toxicology in Vitro. 25:905-913
Paraoxonase 1 (PON1) has been described as a potential catalytic bioscavenger due to its ability to hydrolyze organophosphate (OP) insecticides and nerve agents. In vitro catalytic efficiency of purified human and rabbit serum PON1 against different
Autor:
Yonas Alamneh, Alfred M. Sciuto, Bhupendra P. Doctor, Michael W. Perkins, Madhusoodana P. Nambiar, Peter Rezk, Manojkumar Valiyaveettil
Publikováno v:
Toxicology Letters. 202:203-208
To explore the efficacy of paraoxonase 1 (PON1) as a catalytic bioscavenger, we evaluated human recombinant PON1 (rePON1) expressed in Trichoplusia ni larvae against sarin and soman toxicity using microinstillation inhalation exposure in guinea pigs.