Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Bhuneshwari Patel"'
Autor:
Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
Publikováno v:
Journal of Medicinal Chemistry. 57:2601-2610
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d79521da6469de081b15fb4cf46d71d
https://doi.org/10.1021/jm401858f
https://doi.org/10.1021/jm401858f
Autor:
Shirley M. Williams, Robert G. Aslanian, Christopher Sondey, Sylvia J. Degrado, Ning Shao, Mary Senior, Li Wang, Shuqin Zheng, Joyce J. Hwa, Robert E. West, Ren-Long Wu, Ashwin U. Rao, Anandan Palani, Bhuneshwari Patel, Mckittrick Brian A, Tin-Yau Chan
Publikováno v:
ACS Medicinal Chemistry Letters. 3:198-202
A series of novel 2-piperidinopiperidine thiadiazoles were synthesized and evaluated as new leads of histamine H3 receptor antagonists. The 4-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)morpholine (5u) displayed excellent pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69e721682b06b3634db0e9e970e3aaf
https://doi.org/10.1021/ml200250t
https://doi.org/10.1021/ml200250t
Autor:
Duane, DeMong, Xing, Dai, Joyce, Hwa, Michael, Miller, Sue-Ing, Lin, Ling, Kang, Andrew, Stamford, William, Greenlee, Wensheng, Yu, Michael, Wong, Brian, Lavey, Joseph, Kozlowski, Guowei, Zhou, De-Yi, Yang, Bhuneshwari, Patel, Aileen, Soriano, Ying, Zhai, Christopher, Sondey, Hongtao, Zhang, Jean, Lachowicz, Diane, Grotz, Kathleen, Cox, Richard, Morrison, Teresa, Andreani, Yang, Cao, Mark, Liang, Tao, Meng, Paul, McNamara, Jesse, Wong, Prudence, Bradley, Kung-I, Feng, Jitendra, Belani, Ping, Chen, Peng, Dai, Jolicia, Gauuan, Peishan, Lin, He, Zhao
Publikováno v:
Journal of medicinal chemistry. 57(6)
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7428e9b03dd835df4d86fffa2b642e9e
https://pubmed.ncbi.nlm.nih.gov/24527772
https://pubmed.ncbi.nlm.nih.gov/24527772
Autor:
Melanie B. Henry, Chenxia Duan, Bhuneshwari Patel, Christopher Sondey, Shuqin Zheng, Joyce J. Hwa, Galya Vassileva, Jean E. Lachowicz
Publikováno v:
Endocrinology. 152(3)
Proxyfan is a histamine H3 receptor protean agonist that can produce a spectrum of pharmacological effects including agonist, inverse agonist, and antagonist. We have discovered that proxyfan (10 mg/kg orally) significantly improved glucose excursion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29db4db090b04a601a5ea06ed860c70
https://pubmed.ncbi.nlm.nih.gov/21239440
https://pubmed.ncbi.nlm.nih.gov/21239440