NADH fluorescence lifetime imaging microscopy reveals selective mitochondrial dysfunction in neurons overexpressing alzheimer’s disease–related proteins

Autor: Niederschweiberer, Moritz A., Schaefer, Patrick M., Singh, Larry N., Lausser, Ludwig, Bhosale, Devyani, Hesse, Raphael, Calzia, Enrico, Kestler, Hans A., Rueck, Angelika, Wallace, Douglas C., von Einem, Bjoern, von Arnim, Christine A. F.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::05797cf5e3db91f00d327f23bcaada74

NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins.

Autor: Niederschweiberer MA; Department of Neurology, Ulm University, Ulm, Germany.; Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Schaefer PM; Department of Neurology, Ulm University, Ulm, Germany.; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania, Philadelphia, PA, United States., Singh LN; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania, Philadelphia, PA, United States., Lausser L; Institute of Medical Systems Biology, Ulm University, Ulm, Germany., Bhosale D; Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, United States., Hesse R; Department of Neurology, Ulm University, Ulm, Germany., Calzia E; University Medical School, Institute of Anesthesiological Pathophysiology and Process Engineering, Ulm, Germany., Kestler HA; Institute of Medical Systems Biology, Ulm University, Ulm, Germany., Rueck A; Core Facility Confocal and Multiphoton Microscopy, Ulm University, Ulm, Germany., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania, Philadelphia, PA, United States.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States., von Einem B; Department of Neurology, Ulm University, Ulm, Germany., von Arnim CAF; Department of Neurology, Ulm University, Ulm, Germany.; Division of Geriatrics, University Medical Center Göttingen, Göttingen, Germany.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2021 Jun 14; Vol. 8, pp. 671274. Date of Electronic Publication: 2021 Jun 14 (Print Publication: 2021).