Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bhooshan Kafle"'
Autor:
Manoj Gyawali, Ayusha Acharya, Tikaram Adhikari, Kiran Dahal, Bhooshan Kafle, Dae Hyun Kim, Sagar Kafle
Publikováno v:
Bibechana, Vol 19, Iss 1-2 (2022)
Postharvest loss of vegetables and fruits is higher in developing countries due to the lack of post-processing equipment. Although the production of ginger and turmeric is high in Nepal, farmers practices open sun drying, which leads to poor quality,
Externí odkaz:
https://doaj.org/article/f4a79b5aab7149bb8c5efef024c3780a
Publikováno v:
Bulletin of the Korean Chemical Society. 37:621-625
SA37 inhibits protein tyrosine phosphatase 1B (PTP1B) with a medium potency, and inhibits IκB kinase β (IKKβ) at a submicromolar half-maximal inhibitory concentration. In animal study, SA37 reduced diet-induced weight gain in mice, without signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e984eed1c15fb4e6562063c2b4ff38
https://doi.org/10.1002/bkcs.10730
https://doi.org/10.1002/bkcs.10730
Publikováno v:
Bulletin of the Korean Chemical Society. 34:2487-2490
SA51, a medium potency inhibitor of protein tyrosine phosphatase 1B (PTP1B), was identified to be a potent inhibitor of kinase (). Consistent with this, SA51 prevented lipopolysaccharide (LPS)-induced breakdown of in macrophages. The effects of SA51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b8fc90b428e9999828a58ccd3934bb4
https://doi.org/10.5012/bkcs.2013.34.8.2487
https://doi.org/10.5012/bkcs.2013.34.8.2487
Autor:
Seung Wook Ham, Inn-Oc Han, Ji-Sun Hwang, Bharat Raj Bhattarai, Bhooshan Kafle, Hyeongjin Cho, Keun-Hyeung Lee, Hwangseo Park
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6758-6763
Benzylidene-2,4-thiazolidinedione derivatives with substitutions at both the ortho and para-positions of the phenyl group were synthesized as PTP1B inhibitors with IC(50) values in a low micromolar range. Compound 18l, the lowest, bore an IC(50) of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2033c6b1c26e579897d053381db1b
https://doi.org/10.1016/j.bmcl.2010.08.130
https://doi.org/10.1016/j.bmcl.2010.08.130
Autor:
Ji-Sun Hwang, Sun-Myung Lee, Hwangseo Park, Inn-Oc Han, Deegendra Khadka, Bhooshan Kafle, Seung Wook Ham, Jae Seung Kang, Bharat Raj Bhattarai, Hyeongjin Cho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6161-6165
Benzylidene-2,4-thiazolidinedione derivatives with substitutions on the phenyl ring at the ortho or para positions of the thiazolidinedione (TZD) group were synthesized as PTP1B inhibitors with IC50 values in a low micromolar range. Compound 3e, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd064cdfe59b7e8970186071be67406
https://doi.org/10.1016/j.bmcl.2009.09.020
https://doi.org/10.1016/j.bmcl.2009.09.020
Autor:
Dong Yoon Lee, Hyeongjin Cho, Bharat Raj Bhattarai, Mee-Kyung Kim, Jae Seung Kang, Keun-Hyeung Lee, Mi-Jeong Kim, Bhooshan Kafle
Publikováno v:
Bulletin of the Korean Chemical Society. 29:342-346
Aurintricarboxylic acid (ATA) prevents apoptosis in a wide range of cell types, including PC12 cells. ATA isknown to increase the phosphorylation level of IGF-1 receptor (IGF-1R) and downstream signaling proteins.ATA can translocate across the plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::081ab3582d38a6564b6199d80fc6e7d4
https://doi.org/10.5012/bkcs.2008.29.2.342
https://doi.org/10.5012/bkcs.2008.29.2.342
Publikováno v:
Bulletin of the Korean Chemical Society. 34:1275-1277
Given that a PTP controls the duration ofthe phosphorylation state of a protein, suppression of theactivity of the PTP could be an effective way to prolong thesignal induced by tyrosine phosphorylation. For example,inhibition of PTP1B, a major phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fc8a276dbf4be39de3ca02f50b546eb
https://doi.org/10.5012/bkcs.2013.34.4.1275
https://doi.org/10.5012/bkcs.2013.34.4.1275
Autor:
Bhooshan Kafle, Hyeongjin Cho
Publikováno v:
Bulletin of the Korean Chemical Society. 33:275-277
E-mail: hcho@inha.ac.krReceived June 27, 2011, Accepted September 15, 2011Key Words : Isoxazol-5(4H)-one, Protein tyrosine phosphatase, Inhibitor, PTP1BMetabolic syndromes such as obesity and diabetes poseserious health threats in modern society. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c4201e4f142d49ee9efbe7d830b391
https://doi.org/10.5012/bkcs.2012.33.1.275
https://doi.org/10.5012/bkcs.2012.33.1.275
Publikováno v:
ChemInform. 42
Synthesis and assay for inhibitory activity against human protein tyrosine phosphatase PTB1B are given.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a5852eeb3784cd454648d1ad07e2f7
https://doi.org/10.1002/chin.201122172
https://doi.org/10.1002/chin.201122172
Autor:
Hyeongjin Cho, Bhooshan Kafle, Bharat Raj Bhattarai, Jeong-Hyeon Ko, Suja Shrestha, Heeyeong Cho, Ju-Hee Kang
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
In a previous study, protein tyrosine phosphatase 1B (PTP1B) inhibitors, SA18 and SA32, exhibited anti-obesity effects in a mouse model by suppressing weight gain and improving blood parameters, including free fatty acid (FFA) levels. In a separate s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f136ce0468bf34d675b94d01bdad29d
https://pubmed.ncbi.nlm.nih.gov/20044255
https://pubmed.ncbi.nlm.nih.gov/20044255