Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bhooma Raghavan"'
Autor:
Kevin Skoblenick, Swapna Bhagwanth, Ram K. Mishra, Rodney L. Johnson, Niran Argintaru, Bhooma Raghavan
Publikováno v:
Journal of Medicinal Chemistry. 52:2043-2051
Type II beta-turn mimics and polyproline II helix mimics based upon diastereoisomeric 5.6.5 spiro bicyclic scaffolds have provided two pairs of Pro-Leu-Gly-NH(2) (PLG) peptidomimetics with contrasting dopamine receptor modulating activities. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91232570cb99b5622f45d52b764361b
https://doi.org/10.1021/jm801575w
https://doi.org/10.1021/jm801575w
Autor:
Bhooma Raghavan, Rodney L. Johnson
Publikováno v:
The Journal of Organic Chemistry. 71:2151-2154
A concise, stereoselective synthesis of α-substituted γ-lactams is reported. γ-Lactam scaffolds 2 and 3, possessing an Evans' chiral auxiliary and two types of N substituents, were successfully alkylated with different electrophiles to give α-sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a46d75b1208b98524b97fc792ae9444
https://doi.org/10.1021/jo052212q
https://doi.org/10.1021/jo052212q
A stereoselective total synthesis of the cytotoxic natural products tubulysin U, tubulysin V, and its unnatural epimer epi-tubulysin V, is reported. A series of simplified analogs containing N,N-dimethyl-D-alanine as a replacement for the N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4548917114cf88b2f0929b8f1f9bb726
https://europepmc.org/articles/PMC4183140/
https://europepmc.org/articles/PMC4183140/
Autor:
Ranganathan Balasubramanian, Dan L. Sackett, Jaeson C. Steele, Bhooma Raghavan, Robert A. Fecik
Publikováno v:
Journal of medicinal chemistry. 51(6)
An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ada6991cd40e59168ff1fd9482aaa0
https://pubmed.ncbi.nlm.nih.gov/18314944
https://pubmed.ncbi.nlm.nih.gov/18314944
Autor:
Jaeson C. Steele, Robert A. Fecik, Dan L. Sackett, Bhooma Raghavan, Ranganathan Balasubramanian
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(9)
A series of tubulysin analogs in which one of the stereogenic centers of tubuphenylalanine was eliminated were synthesized. All compounds were tested for antiproliferative activity towards ovarian cancer cells and for inhibition of tubulin polymeriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017b63a64f05a82bb0df96dbe33e1769
https://pubmed.ncbi.nlm.nih.gov/18411048
https://pubmed.ncbi.nlm.nih.gov/18411048
Autor:
Bhooma, Raghavan, Rodney L, Johnson
Publikováno v:
The Journal of organic chemistry. 71(5)
A concise, stereoselective synthesis of alpha-substituted gamma-lactams is reported. gamma-Lactam scaffolds 2 and 3, possessing an Evans' chiral auxiliary and two types of N substituents, were successfully alkylated with different electrophiles to gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e82296d9bcefb0e68178b275ce788e6
https://pubmed.ncbi.nlm.nih.gov/16497007
https://pubmed.ncbi.nlm.nih.gov/16497007
Autor:
Bhooma Raghavan, Kevin J. Skoblenick, Swapna Bhagwanth, Niran Argintaru, Ram K. Mishra, Rodney L. Johnson
Publikováno v:
Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p2043-2051, 9p
Autor:
Bhooma Raghavan, Ranganathan Balasubramanian, Jaeson C. Steele, Robert A. Fecik, Dan L. Sackett
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1530-1533, 4p