Macrophage expressed tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis progression.

Autor: Bergwik J; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Bhongir RKV; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Padra M; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Adler A; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Olm F; Lund Stem Cell Center, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.; Cardiothoracic Surgery, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Lång P; Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Lindstedt S; Lund Stem Cell Center, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.; Cardiothoracic Surgery, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Andersson G; Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Egesten A; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden., Tanner L; Respiratory Medicine, Allergology & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.

Publikováno v: Immunology [Immunology] 2024 Apr; Vol. 171 (4), pp. 583-594. Date of Electronic Publication: 2024 Jan 04.

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.

Autor: Tanner L; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden. lloyd.tanner@med.lu.se., Single AB; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Bhongir RKV; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Heusel M; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Mohanty T; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Karlsson CAQ; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Pan L; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Clausson CM; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden., Bergwik J; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Wang K; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Andersson CK; Respiratory Cell Biology, Department of Experimental Medical Sciences Lund, Lund University, SE-221 84, Lund, Sweden., Oommen RM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden., Erjefält JS; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden., Malmström J; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden., Boldogh I; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.; Oxcia AB, Norrbackagatan 70C, SE-113 34, Stockholm, Sweden.; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2RX, UK., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.; Oxcia AB, Norrbackagatan 70C, SE-113 34, Stockholm, Sweden., Egesten A; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 06; Vol. 14 (1), pp. 643. Date of Electronic Publication: 2023 Feb 06.

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation.

Autor: Tanner L; Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund University and Skåne University Hospital, Lund, Sweden., Bergwik J; Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund University and Skåne University Hospital, Lund, Sweden., Bhongir RKV; Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund University and Skåne University Hospital, Lund, Sweden., Pan L; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States., Dong C; Unit of Experimental Asthma and Allergy Research, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden., Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Oxcia AB, Stockholm, Sweden., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Oxcia AB, Stockholm, Sweden.; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom., Boldogh I; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States., Adner M; Unit of Experimental Asthma and Allergy Research, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden., Egesten A; Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund University and Skåne University Hospital, Lund, Sweden.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2022 Oct 17; Vol. 13, pp. 999180. Date of Electronic Publication: 2022 Oct 17 (Print Publication: 2022).

Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions.

Autor: Liu, Ya¹ (AUTHOR), Wang, Danxia² (AUTHOR), Liu, Xiang¹ (AUTHOR), Yuan, Haibin³ (AUTHOR), Liu, Dan⁴ (AUTHOR), Hu, Yixiang¹ (AUTHOR) yixianghu@hnu.edu.cn, Ning, Shipeng⁴ (AUTHOR) nspdoctor@sr.gxmu.edu.cn

Publikováno v: Cell Communication & Signaling. 12/5/2024, Vol. 22 Issue 1, p1-17. 17p.

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage.

Autor: Zhong Y; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.; Zhuhai UM Science and Technology Research Institute, Zhuhai, China., Zhang X; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.; Zhuhai UM Science and Technology Research Institute, Zhuhai, China., Feng R; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China., Fan Y; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.; Zhuhai UM Science and Technology Research Institute, Zhuhai, China., Zhang Z; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MoE) of People's Republic of China, College of Pharmacy, Jinan University, Guangzhou, China.; Modernization and Innovative Drug Discovery of Chinese Ministry of Education, Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, China., Zhang QW; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China., Wan JB; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China., Wang Y; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China., Yu H; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China., Li G; Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.; Zhuhai UM Science and Technology Research Institute, Zhuhai, China.

Publikováno v: Medicinal research reviews [Med Res Rev] 2024 Nov; Vol. 44 (6), pp. 2825-2848. Date of Electronic Publication: 2024 Aug 09.