Microdomain-Specific Modulation of L-type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure

Autor: Sanchez-Alonso, JL, Bhargava, A, O'Hara, T, Glukhov, AV, Schobesberger, S, Bhogal, NK, Sikkel, MB, Mansfield, C, Korchev, YE, Lyon, AR, Punjabi, PP, Nikolaev, VO, Trayanova, NA, Gorelik, J

RATIONALE: Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure (HF) and certain arrhythmia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::79023285641cafed990e2c47cceca531
http://hdl.handle.net/10044/1/39657

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β 2 AR-cAMP Responsiveness in Murine Hearts.

Autor: Wright PT; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Bhogal NK; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Diakonov I; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Pannell LMK; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Perera RK; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Bork NI; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schobesberger S; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Lucarelli C; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; Department of Cardiac Surgery, University of Verona School of Medicine, Azienda Ospedalieria Universitaria Integrata, Borgo Trento Piazzale A. Stefani, 37126 Verona, Italy., Faggian G; Department of Cardiac Surgery, University of Verona School of Medicine, Azienda Ospedalieria Universitaria Integrata, Borgo Trento Piazzale A. Stefani, 37126 Verona, Italy., Alvarez-Laviada A; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Zaccolo M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK., Kamp TJ; Department of Medicine, University of Wisconsin Madison, 1111 Highland Ave., Madison, WI 53705-2275, USA., Balijepalli RC; Department of Medicine, University of Wisconsin Madison, 1111 Highland Ave., Madison, WI 53705-2275, USA., Lyon AR; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London SW7 3AZ, UK., Harding SE; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Gorelik J; Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. Electronic address: j.gorelik@imperial.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2018 Apr 10; Vol. 23 (2), pp. 459-469.