Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bheemarao G. Ugarkar"'
Publikováno v:
Drug Discovery and Drug Development ISBN: 9789811580017
India has the task of eliminating tuberculosis (TB) by 2025. This translates to curing about two million TB cases present today as well as reducing the TB infection rates rapidly (WHO Global Tuberculosis Report 2017). The ‘standard treatment regime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60fdc80a3d0e6c9ab7dd3ab911aaea2f
https://doi.org/10.1007/978-981-15-8002-4_2
https://doi.org/10.1007/978-981-15-8002-4_2
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Autor:
Rajesh Kalkhambkar, Bheemarao G. Ugarkar, Jon Read, Martin Vogtherr, Beena Paul, Swati Prasad, Adrian Liam Gill, Shantika Bhat, Helen H.J. McMiken, Maruti Naik, Jyothi Bhat, Julie A. Tucker, Kevin J. Embrey, Begur Vasanthkumar Varun, Balachandra Bandodkar, Rani Menon, Syeed Hussein, Janani Venkatraman, Kannan Murugan, Harini Iyer, Anandkumar Raichurkar, Manoranjan Panda
Publikováno v:
Journal of Medicinal Chemistry. 58:753-766
M. tuberculosis thymidylate kinase (Mtb TMK) has been shown in vitro to be an essential enzyme in DNA synthesis. In order to identify novel leads for Mtb TMK, we performed a high throughput biochemical screen and an NMR based fragment screen through
Autor:
Vikas Shinde, Bheemarao G. Ugarkar, Jayashree Puttur, Murugan Chinnapattu, Praveena Manjrekar, Gajanan Shanbhag, Vikas Patil, P. Shahul Hameed
Publikováno v:
Synthetic Communications. 43:3315-3321
Short and efficient route for the synthesis of oxazinone- and thiazinone-containing bicyclic heteroaromatic aldehydes, which involves the key step of palladium-catalyzed reductive carbonylation, is described. Overall routes for the synthesis of these
Autor:
Zhili Sun, Deidre A. MacKenna, Bheemarao G Ugarkar, K. Raja Reddy, William Craigo, Serge H. Boyer, Mark D. Erion, Jorge E. Gomez-Galeno, Hongjian Jiang, Julie Esterbrook
Publikováno v:
Journal of Medicinal Chemistry. 49:7711-7720
Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissue
Autor:
Megumi Tsuchiya, James B. Wiesner, Masami Nakane, Atsushi Nagahisa, Michael C. Matelich, Matthew Allan, Robert H Lemus, Brett C. Bookser, Mark D. Erion, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 48:7808-7820
4-(Phenylamino)-5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 1 and related compounds known as "diaryltubercidin" analogues are potent inhibitors of adenosine kinase (AK) and are orally active in animal models of pain such as the
Publikováno v:
Tetrahedron Letters. 44:4109-4112
Sugar intermediates 4- C -methyl-2,3,5-tri- O -benzyl- d -ribofuranose ( 8b ) and 4- C -methyl-2,3,5-tri- O -benzyl- l -lyxofuranose ( 8a ) were synthesized by addition of alkylithium reagents to pentanones 3a , b . The nucleophilic additions proceed
Autor:
Jayashree Puttur, Praveena Manjrekar, Murugan Chinnapattu, Vikas Patil, Gajanan Shanbhag, Vikas Shinde, Bheemarao G. Ugarkar, Shahul Hameed P
Publikováno v:
ChemInform. 45
Autor:
and Juergen M. Schanzer, James B. Wiesner, Jay DaRe, Joseph J. Kopcho, Mark D. Erion, Angelo J. Castellino, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 43:2883-2893
Adenosine receptor agonists produce a wide variety of therapeutically useful pharmacologies. However, to date they have failed to undergo successful clinical development due to dose-limiting side effects. Adenosine kinase inhibitors (AKIs) represent
Autor:
Ross Dixon, Mark D. Erion, James R. Appleman, Jay DaRe, James M. Fujitaki, Angelo J. Castellino, James B. Wiesner, Bheemarao G. Ugarkar
Publikováno v:
Nucleosides and Nucleotides. 16:1013-1021
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplished in 4