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Autor:
Nina M. Goodey, Bheemanoboina Rry, Tyler Eck, John J. Siekierka, Ramappa Chakrasali, Purnima Bhanot, Laureano de Souza M, Tamara Kreiss, David P. Rotella
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Structurally novel isoxazole-based compounds were shown to be ATP competitive inhibitors of PfPKG. Isoxazoles 3 and 5 had Ki values of 0.7 ± 0.2 and 2.3 ±
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354171d010b685e50cfad3da790134e4
https://doi.org/10.1101/2021.06.24.449800
https://doi.org/10.1101/2021.06.24.449800