Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Bhavna, Kantesaria"'
Autor:
Marissa F, Dockendorf, David, Jaworowicz, Rebecca, Humphrey, Melanie, Anderson, Sheila, Breidinger, Lei, Ma, Theresa, Taylor, Nicole, Dupre, Christopher, Jones, Christine, Furtek, Bhavna, Kantesaria, Kevin P, Bateman, Eric, Woolf, Michael F, Egan, Julie A, Stone
Publikováno v:
The AAPS Journal. 24
In-clinic venous dried blood spot (DBS) pharmacokinetic (PK) sampling was incorporated into two phase 3 studies of verubecestat for Alzheimer's disease (EPOCH [NCT01739348] and APECS [NCT01953601]), as a potential alternative to plasma PK sampling. I
Autor:
Brittany Walker, Amanda Paschke, Mallika Lala, Bhavna Kantesaria, Matthew L. Rizk, Michelle L Brown
Publikováno v:
The Journal of Clinical Pharmacology. 59:646-653
In patients with renal insufficiency, dose adjustments based on creatinine clearance and body weight have been a component of imipenem dosage instructions. The objective of the current analysis was to provide revised dosing recommendations by evaluat
Autor:
Joanna Udo de Haes, Marian Iwamoto, Azra Hussaini, Fang Liu, Carolyn R. Cho, Melissa Drexel, Sreeraj Macha, Bhavna Kantesaria, William L. Marshall, Heather R. Jordan, Arne van Schanke, Joan R. Butterton, Karsten Menzel, Ellen G. J. Hulskotte, Christine Tsai, Jacqueline B. McCrea
Publikováno v:
The Journal of Clinical Pharmacology. 58:897-904
Letermovir is a human cytomegalovirus terminase inhibitor for cytomegalovirus infection prophylaxis in hematopoietic stem cell transplant recipients. Posaconazole (POS), a substrate of glucuronosyltransferase and P-glycoprotein, and voriconazole (VRC
Autor:
Eric Woolf, Melanie Anderson, Marie-Josée Marcoux, Li Sun, Philippe Bélanger, Vincent Trinh, Sheila Breidinger, Bhavna Kantesaria, Yang Xu, Dina Goykhman, Kevin P. Bateman, Patricia Lavallée
Publikováno v:
Journal of Chromatography B. 1063:50-59
MK-1293 is a newly approved follow-on/biosimilar insulin glargine for the treatment of Type 1 and Type 2 diabetics. To support pivotal clinical studies during biosimilar evaluation, a sensitive, specific and robust liquid chromatography and tandem ma
Autor:
Bhavna Kantesaria, Bharath Kumar, Paul Statkevich, Christine McCrary Sisk, David L. Cutler, Teddy Kosoglou, James E. Schiller, Mary E. Hanson
Publikováno v:
Clinical Pharmacology in Drug Development. 4:56-62
Purpose To evaluate the potential effects of vorapaxar on the pharmacokinetics and safety of rosiglitazone. Methods This was an open-label, two-period, two-treatment, fixed-sequence study in 18 healthy subjects. On Day 1, Period 1, subjects received
Autor:
Teddy Kosoglou, Amy O. Johnson-Levonas, Mona Yunan, James Hubbell, David L. Cutler, Bhavna Kantesaria
Publikováno v:
Clinical Pharmacology in Drug Development. 3:222-228
A fixed-dose combination (FDC) containing mometasone furoate (MF) and formoterol fumarate (F) in a pressurized metered dose inhaler (MDI) is approved for asthma and is being developed for COPD. This randomized, open-label, 4-period crossover study co
Publikováno v:
Clinical Pharmacology in Drug Development. 3:229-234
Purpose This randomized, open-label, multiple-dose, two-period, crossover study compared the systemic bioavailability of mometasone furoate (MF) administered from a metered-dose inhaler containing MF and formoterol fumarate (F) (MF/F-MDI) versus MF a
Publikováno v:
Drug Discoveries & Therapeutics. 8:89-95
Although ribavirin is minimally cleared by renal elimination, its pharmacokinetics are substantially altered in patients with chronic renal impairment. This open-label study assessed the pharmacokinetics of single 400-mg oral and intravenous (IV) dos
Autor:
Karen Small, Bhavna Kantesaria, Paul Statkevich, Rajat Bannerji, A. Tzontcheva, Geoffrey I. Shapiro, Monica M. Mita, Yali Zhu, Da Zhang, Jennifer Poon
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:891-898
Dinaciclib, a selective inhibitor of cyclin-dependent kinase (CDK) 1, CDK2, CDK5, and CDK9, is metabolized via CYP3A4. Aprepitant, a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting, is an inhibitor and
Publikováno v:
European Journal of Clinical Pharmacology. 68:415-418
This study describes the pharmacokinetics, safety, and tolerability of ribavirin in hemodialysis-dependent patients.Six adult patients (4 male, 2 female) were recruited from a hemodialysis clinic where they were receiving regular hemodialysis session