Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bhavitavya Nijampatnam"'
Publikováno v:
ACS Omega, Vol 3, Iss 7, Pp 8378-8385 (2018)
Externí odkaz:
https://doaj.org/article/d3361288701645a08da49a8c942b3519
Autor:
Qiong Zhang, Bhavitavya Nijampatnam, Zhang Hua, Thao Nguyen, Jing Zou, Xia Cai, Suzanne M. Michalek, Sadanandan E. Velu, Hui Wu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms. Therefore, the inhibition of GtfBCD would provide anti-virulence therapeutics. Here a small molecule library of
Externí odkaz:
https://doaj.org/article/fd06f20a37b34ee2a6b0c326fa712604
Autor:
M. Ryan Smith, Praveen K. Vayalil, Fen Zhou, Gloria A. Benavides, Reena R. Beggs, Hafez Golzarian, Bhavitavya Nijampatnam, Patsy G. Oliver, Robin A.J. Smith, Michael P. Murphy, Sadanandan E. Velu, Aimee Landar
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 136-148 (2016)
Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and am
Externí odkaz:
https://doaj.org/article/28598c4d4dc14203b4dba36a2bf4aa84
Publikováno v:
Microorganisms, Vol 2, Iss 3, Pp 128-139 (2014)
Streptococcus mutans is a key etiological agent in the formation of dental caries. The major virulence factor is its ability to form biofilms. Inhibition of S. mutans biofilms offers therapeutic prospects for the treatment and the prevention of denta
Externí odkaz:
https://doaj.org/article/297b9ce60ce0401a9383d719bb3c79c1
Publikováno v:
Marine Drugs, Vol 14, Iss 1, p 17 (2016)
The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special intere
Externí odkaz:
https://doaj.org/article/75e8c17705714794b689048dbea222ca
Autor:
James Ross Terrell, Sijia Tang, Oluwafoyinsola Omobodunde Faniyi, In Ho Jeong, Jun Yin, Bhavitavya Nijampatnam, Sadanandan E. Velu, Wei Wang, Ruiwen Zhang, Ming Luo
Publikováno v:
Protein Science. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::047a04545ac38ef08241e95a99e73676
https://doi.org/10.1002/pro.4367
https://doi.org/10.1002/pro.4367
Autor:
Suzanne M. Michalek, Hua Zhang, Holly Womack, Xia Cai, Bhavitavya Nijampatnam, Sadanandan E. Velu, Piyasuda Pukkanasut, Parmanand Ahirwar, Luke Casals, Hui Wu
Publikováno v:
ACS Medicinal Chemistry Letters. 12:48-55
Dental caries is a bacterial infectious disease characterized by demineralization of the tooth enamel. Treatment of this disease with conventional antibiotics is largely ineffective as the cariogenic bacteria form tenacious biofilms that are resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0108e9ed376f11b70ede691e79963e
https://doi.org/10.1021/acsmedchemlett.0c00373
https://doi.org/10.1021/acsmedchemlett.0c00373
Autor:
James Ross, Terrell, Sijia, Tang, Oluwafoyinsola Omobodunde, Faniyi, In Ho, Jeong, Jun, Yin, Bhavitavya, Nijampatnam, Sadanandan E, Velu, Wei, Wang, Ruiwen, Zhang, Ming, Luo
Publikováno v:
Protein science : a publication of the Protein Society. 31(8)
Mouse double minute 2 homolog (MDM2) is an E3 ubiquitin-protein ligase that is involved in the transfer of ubiquitin to p53 and other protein substrates. The expression of MDM2 is elevated in cancer cells and inhibitors of MDM2 showed potent anticanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b661376541ee9e567b12cf67b09cc63
https://pubmed.ncbi.nlm.nih.gov/35900024
https://pubmed.ncbi.nlm.nih.gov/35900024
Autor:
Bhavitavya, Nijampatnam, Parmanand, Ahirwar, Piyasuda, Pukkanasut, Holly, Womack, Luke, Casals, Hua, Zhang, Xia, Cai, Suzanne M, Michalek, Hui, Wu, Sadanandan E, Velu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Dental caries is a bacterial infectious disease characterized by demineralization of the tooth enamel. Treatment of this disease with conventional antibiotics is largely ineffective as the cariogenic bacteria form tenacious biofilms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::096c907fa5c7d35361df2809af7c179a
https://pubmed.ncbi.nlm.nih.gov/33488963
https://pubmed.ncbi.nlm.nih.gov/33488963
Autor:
Sadanandan E. Velu, Jiang-Jiang Qin, Ke-He Ruan, Sukesh Voruganti, Ruiwen Zhang, Wei Wang, Bhavitavya Nijampatnam, Jianwei Zhou, Ming Hu
Publikováno v:
Cancer Research. 78:5656-5667
Overexpression and activation of the murine double minute 2 (MDM2) or nuclear factor of activated T cells 1 (NFAT1) oncoproteins frequently occur in pancreatic cancer. Most MDM2 inhibitors under development target MDM2–p53 binding and have little o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a3bfd1cf158be4fec76ed379c702f4
https://doi.org/10.1158/0008-5472.can-17-3939
https://doi.org/10.1158/0008-5472.can-17-3939