Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Bhavesh D, Kevadiya"'
Autor:
Farhana Islam, Srijanee Das, Md Ashaduzzaman, Brady Sillman, Pravin Yeapuri, Mohammad Ullah Nayan, David Oupický, Howard E. Gendelman, Bhavesh D. Kevadiya
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug’
Externí odkaz:
https://doaj.org/article/724d71a1580b4ef987734da42550c3e9
Autor:
Suyash Deodhar, Brady Sillman, Aditya N. Bade, Sean N. Avedissian, Anthony T. Podany, JoEllyn M. McMillan, Nagsen Gautam, Brandon Hanson, Bhagya L. Dyavar Shetty, Adam Szlachetka, Morgan Johnston, Michellie Thurman, Daniel J. Munt, Alekha K. Dash, Milica Markovic, Arik Dahan, Yazen Alnouti, Alborz Yazdi, Bhavesh D. Kevadiya, Siddappa N. Byrareddy, Samuel M. Cohen, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, using animal models, Deodhar et al. single parenteral dose of dolutegravir (DTG) prodrug nanocrystals sustains drug protein-adjusted 90% inhibitory concentration for up to a year, without injection site reactions or systemic toxicities.
Externí odkaz:
https://doaj.org/article/0e6c6ddce7834d67b915c46f752da67f
Autor:
Tapan A. Patel, Bhavesh D. Kevadiya, Neha Bajwa, Preet Amol Singh, Hong Zheng, Annet Kirabo, Yu-Long Li, Kaushik P. Patel
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1877 (2023)
Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various
Externí odkaz:
https://doaj.org/article/39c7879f0cc7426e88c9e63703724f92
Autor:
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-23 (2021)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodegeneration. Neuroinf
Externí odkaz:
https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05
Autor:
Shobha Regmi, Daniel Dan Liu, Michelle Shen, Bhavesh D. Kevadiya, Abantika Ganguly, Rosita Primavera, Shashank Chetty, Reza Yarani, Avnesh S. Thakor
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Alzheimer’s disease (AD) is a major cause of age-related dementia and is characterized by progressive brain damage that gradually destroys memory and the ability to learn, which ultimately leads to the decline of a patient’s ability to perform da
Externí odkaz:
https://doaj.org/article/0273d0cffa494abe875ff996057feca8
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
Autor:
Jatin Machhi, Bhavesh D. Kevadiya, Ijaz Khan Muhammad, Jonathan Herskovitz, Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-26 (2020)
Abstract Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs)
Externí odkaz:
https://doaj.org/article/6642148324e04928a77740aef34287ab
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have e
Externí odkaz:
https://doaj.org/article/4e2416340179418f88dc464b1d8bfb63
Autor:
Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D Kevadiya, K C Kent Lloyd, Howard E Gendelman, Santhi Gorantla, Larisa Y Poluektova, Prasanta K Dash
Publikováno v:
Journal of Leukocyte Biology. 112:1285-1295
The HIV-1 often evades a robust antiretroviral-mediated immune response, leading to persistent infection within anatomically privileged sites including the CNS. Continuous low-level infection occurs in the presence of effective antiretroviral therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56a8fda37a9f71f0ee03a9d5baa35d1
https://doi.org/10.1002/jlb.5vmr0322-161r
https://doi.org/10.1002/jlb.5vmr0322-161r
Autor:
Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya
Publikováno v:
ACS Chemical Neuroscience. 13:1232-1244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37cd2d6b4472a082568878ddd77907f2
https://doi.org/10.1021/acschemneuro.1c00847
https://doi.org/10.1021/acschemneuro.1c00847
Autor:
Xue Liu, Qian Xu, Qiuhua Wu, Yang Wu, Cheng Jiamin, Yulin Liu, Bhavesh D. Kevadiya, Manling Chen, Yang Li, Guolin Zhang, Avnesh S. Thakor
Publikováno v:
Acta Biomaterialia. 136:485-494
Carbon nanodots based on L-arginine (L-Arg) were developed for enhanced nitric oxide (NO) gas therapy for cancer. The L-Arg-based carbon nanodots (Arg-dots) produced high levels of NO in the tumor environment rich in endogenous H2O2. In vitro cell ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d26cd8eb077831730cc67bbfad5aa1
https://doi.org/10.1016/j.actbio.2021.09.051
https://doi.org/10.1016/j.actbio.2021.09.051