Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

Autor: Emily Locke, Yevel Flores-Garcia, Bryan T. Mayer, Randall S. MacGill, Bhavesh Borate, Berenice Salgado-Jimenez, Monica W. Gerber, Shamika Mathis-Torres, Sarah Shapiro, C. Richter King, Fidel Zavala

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)

Abstract New strategies are needed to reduce the incidence of malaria, and promising approaches include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria vaccine, RTS,S/AS01, it is essential to standardize preclinical

Externí odkaz: https://doaj.org/article/cb9a8e98e3904d03ab567757f16ec3bd

Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

Autor: Youyi Fong, Yunda Huang, David Benkeser, Lindsay N. Carpp, Germán Áñez, Wayne Woo, Alice McGarry, Lisa M. Dunkle, Iksung Cho, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Julia Hutter, Maryam Keshtkar-Jahromi, Tatiana H. Beresnev, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Julie A. Ake, Cynthia L. Gay, Karen L. Kotloff, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, Immune Assays Team, Coronavirus Vaccine Prevention Network (CoVPN)/2019nCoV-301 Principal Investigators and Study Team, United States Government (USG)/CoVPN Biostatistics Team

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Authors have previously reported on the efficacy and safety of the recombinant spike protein nanoparticle vaccine, NVX-CoV2373, in healthy adults. In this work, they assess anti-spike binding IgG, anti-RBD binding IgG and neutralising antibody titer

Externí odkaz: https://doaj.org/article/f3590fa9e20145b28dc93b73d492a237

The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk

Autor: Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill

Publikováno v: EBioMedicine, Vol 77, Iss , Pp 103886- (2022)

Summary: Background: We aimed to understand host factors that affect discriminatory performance of a transcriptomic signature of tuberculosis risk (RISK11). Methods: HIV-negative adults aged 18–60 years were evaluated in a prospective study of RISK

Externí odkaz: https://doaj.org/article/1a05f45fbb97478f8d9a44256aabf744

Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

Autor: Simon C Mendelsohn, MBChB, Andrew Fiore-Gartland, PhD, Adam Penn-Nicholson, PhD, Humphrey Mulenga, MPH, Stanley Kimbung Mbandi, PhD, Bhavesh Borate, MS, Katie Hadley, PhD, Chris Hikuam, PhD, Munyaradzi Musvosvi, PhD, Nicole Bilek, PhD, Mzwandile Erasmus, BSc, Lungisa Jaxa, BTech, Rodney Raphela, BSc, Onke Nombida, GT, Masooda Kaskar, MBChB, Tom Sumner, PhD, Richard G White, PhD, Craig Innes, MBChB, William Brumskine, MBChB, Andriëtte Hiemstra, MBChB, Stephanus T Malherbe, MBChB, Razia Hassan-Moosa, MPH, Michèle Tameris, MBChB, Gerhard Walzl, MBChB, Kogieleum Naidoo, PhD, Gavin Churchyard, PhD, Thomas J Scriba, DPhil, Mark Hatherill, ProfMD, Charmaine Abrahams, Hadn Africa, Petri Ahlers, Denis Arendsen, Tebogo Badimo, Kagiso Baepanye, Kesenogile Edna Baepanye, Bianca Bande, Nomfuneko Cynthia Batyi, Roslyn Beukes, Laudicia Tshenolo Bontsi, Obakeng Peter Booi, Mari Cathrin Botha, Samentra Braaf, Sivuyile Buhlungu, Alida Carstens, Kgomotso Violet Chauke, Thilagavathy Chinappa, Eva Chung, Michelle Chung, Ken Clarke, Yolundi Cloete, Lorraine Coetzee, Marelize Collignon, Alessandro Companie, Cara-mia Corris, Mooketsi Theophillius Cwaile, Thobelani Cwele, Ilse Davids, Isabella Johanna Davies, Emilia De Klerk, Marwou de Kock, Audrey Lebohang Dhlamini, Bongani Diamond, Maria Didloff, Celaphiwe Dlamini, Palesa Dolo, Candice Eyre, Tebogo Feni, Juanita Ferreira, Christal Ferus, Michelle Fisher, Marika Flinn, Bernadine Fransman, Welseh Phindile Galane, Hennie Geldenhuys, Diann Gempies, Thelma Goliath, Dhineshree Govender, Yolande Gregg, Goodness Gumede, Zanele Gwamada, Senzo Halti, Rieyaat Hassiem, Roxane Herling, Yulandi Herselman, Ellis Hughes, Henry Issel, Blanchard Mbay Iyemosolo, Zandile Jali, Bonita Janse Van Rensburg, Ruwiyda Jansen, James Michael Jeleni, Olebogeng Jonkane, Fabio Julies, Fazlin Kafaar, Christian Mabika Kasongo, Sophie Keffers, Boitumelo Sophy Kekana, Sebaetseng Jeanette Kekana, Xoliswa Kelepu, Lungile Khanyile, Gomotsegang Virginia Khobedi, Gloria Khomba, Lucky Sipho Khoza, Marietjie King, Gloria Keitumetse Kolobe, Sandra Kruger, Jaftha Kruger, Ndlela Israel Kunene, Sunelza Lakay, Aneesa Lakhi, Nondumiso Langa, Hildah Ledwaba, Lerato Julia Lekagane, Sheiley Christina Lekotloane, Thelma Leopeng, Ilze Jeanette Louw, Angelique Kany Kany Luabeya, Sarah Teboso Lusale, Perfect Tiisetso Maatjie, Immaculate Mabasa, Tshegofatso Dorah Mabe, Kamogelo Fortunate Mabena, Nkosinathi Charles Mabuza, Simbarashe Mabwe, Johanna Thapelo Madikwe, Octavia Mahkosazana Madikwe, Rapontwana Letlhogonolo Maebana, Malobisa Sylvester Magwasha, Molly Majola, Mantai Makhetha, Lebohang Makhethe, Vernon Malay, Vutlhari-I-Vunhenha Fairlord Manzini, Jabu Maphanga, Nonhle Maphanga, Juanita Market, Isholedi Samuel Maroele, Omphile Petunia Masibi, July Rocky Mathabanzini, Tendamudzimu Ivan Mathode, Ellen Ditaba Matsane, Lungile Mbata, Faheema Meyer, Nyasha Karen Mhandire, Thembisiwe Miga, Nosisa Charity Thandeka Mkhize, Caroline Mkhokho, Neo Hilda Mkwalase, Nondzakazi Mnqonywa, Karabo Moche, Brenda Matshidiso Modisaotsile, Patricia Pakiso Mokgetsengoane, Selemeng Matseliso Carol Mokone, Kegomoditswe Magdeline Molatlhegi, Thuso Andrew Molefe, Joseph Panie Moloko, Kabelo Molosi, Motlatsi Evelyn Molotsi, Tebogo Edwin Montwedi, Boikanyo Dinah Monyemangene, Hellen Mokopi Mooketsi, Miriam Moses, Boitumelo Mosito, Tshplpfelo Mapula Mosito, Ireen Lesebang Mosweu, Primrose Mothaga, Banyana Olga Motlagomang, Angelique Mouton, Onesisa Mpofu, Funeka Nomvula Mthembu, Mpho Mtlali, Nhlamulo Ndlovu, Nompumelelo Ngcobo, Julia Noble, Bantubonke Bertrum Ntamo, Gloria Ntanjana, Tedrius Ntshauba, Fajwa Opperman, Nesri Padayatchi, Thandiwe Papalagae, Christel Petersen, Themba Phakathi, Mapule Ozma Phatshwane, Patiswa Plaatjie, Abe Pretorius, Victor Kgothatso Rameetse, Dirhona Ramjit, Frances Ratangee, Maigan Ratangee, Pearl Nomsa Sanyaka, Alicia Sato, Elisma Schoeman, Constance Schreuder, Letlhogonolo Seabela, Kelebogile Magdeline Segaetsho, Ni Ni Sein, Raesibe Agnes Pearl Selepe, Melissa Neo Senne, Alison September, Cashwin September, Moeti Serake, Justin Shenje, Thandiwe Shezi, Sifiso Cornelius Shezi, Phindile Sing, Chandrapharbha Singh, Zona Sithetho, Dorothy Solomons, Kim Stanley, Marcia Steyn, Bongiwe Stofile, Sonia Stryers, Liticia Swanepoel, Anne Swarts, Mando Mmakhora Thaba, Lethabo Collen Theko, Philile Thembela, Mugwena Thompo, Asma Toefy, Khayalethu Toto, Dimakatso Sylvia Tsagae, Ayanda Tsamane, Vincent Tshikovhi, Lebogang Isaac Tswaile, Petrus Tyambetyu, Susanne Tönsing, Habibullah Valley, Linda van der Merwe, Elma van Rooyen, Ashley Veldsman, Helen Veldtsman, Kelvin Vollenhoven, Londiwe Zaca, Elaine Zimri, Mbali Zulu

Publikováno v: The Lancet Global Health, Vol 9, Iss 6, Pp e841-e853 (2021)

Summary: Background: A rapid, blood-based triage test that allows targeted investigation for tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce mortality. We aimed to test the performance of a host blood tra

Externí odkaz: https://doaj.org/article/abc3602cf70749b5a1d464dd9cecb502

Antibody Correlates of Protection From Severe Respiratory Syncytial Virus Disease in a Vaccine Efficacy Trial

Autor: Youyi Fong, Ying Huang, Bhavesh Borate, Lars W P van der Laan, Wenbo Zhang, Lindsay N Carpp, Iksung Cho, Greg Glenn, Louis Fries, Raphael Gottardo, Peter B Gilbert

Publikováno v: Open Forum Infectious Diseases. 10

Background Respiratory syncytial virus (RSV) can cause serious lung infections in young children and there is currently no available vaccine. Methods We used complementary statistical frameworks to analyze 4 RSV serology measurements in mothers and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53496b432c373b1cd4be9490acc7512c
https://doi.org/10.1093/ofid/ofac693