Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bhavana Priyadharshini"'
Autor:
Naoki Tanimine, Sharon K Germana, Martin Fan, Keli Hippen, Bruce R Blazar, James F Markmann, Laurence A Turka, Bhavana Priyadharshini
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217761 (2019)
Regulatory T cells (Tregs) are required for the maintenance of immune tolerance and adoptive Treg infusion therapy has become a promising approach to suppress immune responses in diseases such as autoimmunity and transplant rejection. However, one cr
Externí odkaz:
https://doaj.org/article/fb54bff293ac4bb1a63868934165fafb
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15038 (2010)
The peripheral naïve T cell pool is comprised of a heterogeneous population of cells at various stages of development, which is a process that begins in the thymus and is completed after a post-thymic maturation phase in the periphery. One hallmark
Externí odkaz:
https://doaj.org/article/c94da60d198c4cc1a4c3642a011a5f4e
Autor:
Ryan H. Newton, Jeffrey C. Rathmell, Bhavana Priyadharshini, Michael Loschi, Laurence A. Turka, Alexandria Huynh, Jian Wen Zhang, Kelsey K. Finn, Bruce R. Blazar, Valerie A. Gerriets
Publikováno v:
The Journal of Immunology. 201:2215-2219
Murine Foxp3+ regulatory T cells (Tregs) differentiated in vitro (induced Tregs [iTregs]) in the presence of anti-inflammatory cytokine TGF-β rely predominantly upon lipid oxidation to fuel mitochondrial oxidative phosphorylation. Foxp3 expression u
Publikováno v:
Transplantation. 102:230-239
Recently, a new discipline termed "immunometabolism" has transformed the field of immunology. It encompasses the study of the intrinsic metabolic pathways of different immune subsets and their impact on cellular fate and function. For instance, broad
Autor:
Bruce R. Blazar, Bhavana Priyadharshini, Martin Fan, Naoki Tanimine, Sharon Germana, Laurence A. Turka, Keli L. Hippen, James F. Markmann
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217761 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217761 (2019)
Regulatory T cells (Tregs) are required for the maintenance of immune tolerance and adoptive Treg infusion therapy has become a promising approach to suppress immune responses in diseases such as autoimmunity and transplant rejection. However, one cr
Publikováno v:
Current Opinion in Organ Transplantation. 20:21-28
Purpose of review To highlight some of the recent developments in the novel field of immunometabolism and the therapeutic potential of the many regulatory components of this immunometabolic network for transplantation. Recent findings In response to
The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50cf341b6a33d934a8054bc50078412
https://europepmc.org/articles/PMC5006394/
https://europepmc.org/articles/PMC5006394/
Autor:
Kelsey K. Finn, Jun Siong Low, Naoki Tanimine, Laurence A. Turka, Sharon Germana, Martin Fan, Bhavana Priyadharshini, Susan M. Kaech
Publikováno v:
Cell Reports. 25:1204-1213.e4
Although Foxp3+ regulatory T cells (Tregs) require interleukin-2 (IL-2) for their development, it has been unclear whether continuing IL-2 signals are needed to maintain lineage stability, survival, and suppressor function in mature Tregs. We generat
Autor:
Laura P. Hale, Rigel J. Kishton, Marta E. Slawinska, Olga Ilkayeva, Amanda G. Nichols, Paul Smith, Jason W. Locasale, Andrew N. Macintyre, Mari L. Shinohara, Nancie J. MacIver, Bhavana Priyadharshini, Christopher B. Newgard, Catherine Huck, Jeffrey C. Rathmell, Xiaojing Liu, Makoto Inoue, Laurence A. Turka, Peter S. Winter, Valerie A. Gerriets, Lea Haeberli, Martin A. Schneider, Kris C. Wood
Publikováno v:
The Journal of clinical investigation. 125(1)
Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that mo
Autor:
Raymond M. Welsh, Dale L. Greiner, Bhavana Priyadharshini, Thomas B. Thornley, Michael A. Brehm, Amy Cuthbert, Keith A. Daniels
Publikováno v:
Immunology. 138(4)
Blockade of co-stimulatory signals to T cells is extremely effective for the induction of transplantation tolerance in immunologically naive rodents. However, infections and inflammation compromise the efficacy of co-stimulation blockade regimens for