Výsledky vyhledávání - "Bhavana Kushwaha"

Akademický článek

The thermo-sensitive gene expression signatures of spermatogenesis

Autor: Santosh K. Yadav, Aastha Pandey, Lokesh Kumar, Archana Devi, Bhavana Kushwaha, Rahul Vishvkarma, Jagdamba P. Maikhuri, Singh Rajender, Gopal Gupta

Publikováno v: Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-22 (2018)

Abstract Background Spermatogenesis in most mammals (including human and rat) occurs at ~ 3 °C lower than body temperature in a scrotum and fails rapidly at 37 °C inside the abdomen. The present study investigates the heat-sensitive transcriptome a

Externí odkaz: https://doaj.org/article/b1119588179a4bd6b5d05f33616ef629

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Akademický článek

Designed Chemical Intervention with Thiols for Prophylactic Contraception.

Autor: Monika Sharma, Lokesh Kumar, Ashish Jain, Vikas Verma, Vikas Sharma, Bhavana Kushwaha, Nand Lal, Lalit Kumar, Tara Rawat, Anil K Dwivedi, Jagdamba P Maikhuri, Vishnu L Sharma, Gopal Gupta

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67365 (2013)

Unlike somatic cells, sperm have several-fold more available-thiols that are susceptible to redox-active agents. The present study explains the mechanism behind the instant sperm-immobilizing and trichomonacidal activities of pyrrolidinium pyrrolidin

Externí odkaz: https://doaj.org/article/caebfea36bc54710a5767495bec178dd

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Cell signaling in sperm midpiece ensures quiescence and survival in cauda epididymis

Autor: Gopal Gupta, Jagdamba P. Maikhuri, Bhavana Kushwaha, Rajender Singh, Archana Devi

Publikováno v: Reproduction. 162:339-351

Sperm in most mammalian species including rat, mice and human are kept completely quiescent (motionless) and viable for up to a few weeks in the cauda epididymis before ejaculation. Vigorous motility is initiated almost instantly upon sperm release f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0d64b945ae0725380a5d1a24e3572e
https://doi.org/10.1530/rep-21-0202

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Inflammation driven tumor‐like signaling in prostatic epithelial cells by sexually transmitted Trichomonas vaginalis

Autor: Singh Rajender, Jagdamba P. Maikhuri, Gopal Gupta, Bhavana Kushwaha, Archana Devi

Publikováno v: International Journal of Urology. 28:225-240

Objectives To identify the sequence of inflammation-driven signaling cascades and other molecular events that might cause tumor-like transformation of prostatic cells. Methods Cytokine array analysis, Reactome and STRING analysis, immunoblotting, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34826e0c5d8b3cb895060f98b5ee7383
https://doi.org/10.1111/iju.14431

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Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology

Autor: Nidhi Srivastava, Jagdamba P. Maikhuri, Gopal Gupta, Dhanaraju Mandalapu, Mohammad Imran Siddiqi, Sanjay Krishna, Jawahar Lal, Praveen K. Shukla, Brijesh Kumar, Mahendra Shukla, Sonal Gupta, Bhavana Singh Chauhan, Bhavana Kushwaha, Vishnu L. Sharma, Renu Tripathi, Koneni V. Sashidhara, Pratiksha Singh, Ravi Goyani

Publikováno v: European Journal of Medicinal Chemistry. 143:632-645

Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8ba7575419bdcc6c05d6514110cfe2
https://doi.org/10.1016/j.ejmech.2017.11.060

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MAPK signaling in spermatogenesis and male infertility

Autor: Archana Devi, Bhavana Kushwaha, Gopal Gupta

Publikováno v: Molecular Signaling in Spermatogenesis and Male Infertility ISBN: 9780429244216
Molecular Signaling in Spermatogenesis and Male Infertility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::956700f55e22813fe06d169584cad3e0
https://doi.org/10.1201/9780429244216-10

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2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas : Design, synthesis, biology and 3D-QSAR study

Autor: Nidhi Singh, Mohammad Imran Siddiqi, Jitendra Kumar, Dilip Kumar Tanpula, Jagdamba P. Maikhuri, Bhavana Kushwaha, Gopal Gupta, Dhanaraju Mandalapu, Vishnu L. Sharma, Sonal Gupta, Satya Narayan Sankhwar, Jawahar Lal, Mahendra Shukla

Publikováno v: European Journal of Medicinal Chemistry. 124:820-839

Trichomoniasis is the most prevalent, non-viral sexually transmitted diseases (STD) caused by amitochondriate protozoan Trichomonas vaginalis. Increased resistance of T. vaginalis to the marketed drug Metronidazole necessitates the development of new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7938cf9c8922c8e2d342db646e42adae
https://doi.org/10.1016/j.ejmech.2016.09.006

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Design and synthesis of coumarin–glyoxal hybrids for spermicidal and antimicrobial actions: a dual approach to contraception

Autor: A. K. Srivastava, Jagdamba P. Maikhuri, Gopal Gupta, Anil Kumar Dwivedi, Swati Gupta, Bhavana Kushwaha, Satya Narayan Sankhwar

Publikováno v: RSC Advances. 6:76288-76297

Today there is an urgent need for safe and effective dual-purpose contraceptive agents, which can simultaneously prevent unintended pregnancies and sexually transmitted infections (STI). There are several naturally occurring antimicrobial and antibio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::776371c6b90cc035a20767a3656ae20e
https://doi.org/10.1039/c6ra12156j

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