Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies

Autor: Adedeji K. Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P. Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatri

Publikováno v: iScience, Vol 27, Iss 6, Pp 110068- (2024)

Summary: Most cells in solid tumors are exposed to oxygen levels between 0.5% and 5%. We developed an approach that allows collection, processing, and evaluation of cancer and non-cancer cells under physioxia, while preventing exposure to ambient air

Externí odkaz: https://doaj.org/article/b300f7aa46a649b784ca542379c4f5b4

Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry.

Autor: Bhat-Nakshatri P; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Gao H; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Khatpe AS; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Adebayo AK; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., McGuire PC; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Erdogan C; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Chen D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Jiang G; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., New F; NanoString Technology Inc., Seattle, WA, USA., German R; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Emmert L; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Sandusky G; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Storniolo AM; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Liu Y; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Nakshatri H; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. hnakshat@iu.edu.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. hnakshat@iu.edu.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA. hnakshat@iu.edu.; VA Roudebush Medical Center, Indianapolis, IN, USA. hnakshat@iu.edu.

Publikováno v: Nature medicine [Nat Med] 2024 Aug 09. Date of Electronic Publication: 2024 Aug 09.

A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle

Autor: Ruizhong Wang, Brijesh Kumar, Poornima Bhat-Nakshatri, Aditi S. Khatpe, Michael P. Murphy, Kristen E. Wanczyk, Edward Simpson, Duojiao Chen, Hongyu Gao, Yunlong Liu, Emma H. Doud, Amber L. Mosley, Harikrishna Nakshatri

Publikováno v: iScience, Vol 26, Iss 4, Pp 106541- (2023)

Summary: Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is observed in multiple malignancies. Although mouse models are routinely used to study skeletal muscle defects in cancer, because of species specificity

Externí odkaz: https://doaj.org/article/1438aa9d57ba4cedbd600e0d5b03d86c

Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model

Autor: Ruizhong Wang, Brijesh Kumar, Poornima Bhat‐Nakshatri, Mayuri S. Prasad, Max H. Jacobsen, Gabriela Ovalle, Calli Maguire, George Sandusky, Trupti Trivedi, Khalid S. Mohammad, Theresa Guise, Narsimha R. Penthala, Peter A. Crooks, Jianguo Liu, Teresa Zimmers, Harikrishna Nakshatri

Publikováno v: JCSM Rapid Communications, Vol 4, Iss 1, Pp 24-39 (2021)

Abstract Background Loss of skeletal muscle volume and functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced myoblast determination protein 1 (MyoD) levels and inc

Externí odkaz: https://doaj.org/article/a00e580af8d34f4daa2fee42e2201e27

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis

Autor: Maria B. Padua, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Mayuri S. Prasad, Yangyang Hao, Xi Rao, Sheng Liu, Jun Wan, Yunlong Liu, Kyle McElyea, Max Jacobsen, George Sandusky, Sandra Althouse, Susan Perkins, Harikrishna Nakshatri

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-18 (2018)

Abstract Background The majority of estrogen receptor-positive (ERα+) breast cancers respond to endocrine therapies. However, resistance to endocrine therapies is common in 30% of cases, which may be due to altered ERα signaling and/or enhanced pla

Externí odkaz: https://doaj.org/article/6004230c8bc3416caaf80c8075bbf814