Development, Validation, and Interlaboratory Evaluation of a Quantitative Multiplexing Method To Assess Levels of Ten Endogenous Allergens in Soybean Seed and Its Application to Field Trials Spanning Three Growing Seasons

Autor: Ryan Christopher Hill, Rowel Tobias, Austin Xu, Jason Bradshaw, Guomin Shan, Barry W. Schafer, Trent J. Oman, Bhaskar Malayappan, Li Sheng, Rod A. Herman, Xiujuan Wang, Jeff Shippar

Publikováno v: Journal of Agricultural and Food Chemistry. 65:5531-5544

As part of the regulatory approval process in Europe, comparison of endogenous soybean allergen levels between genetically engineered (GE) and non-GE plants has been requested. A quantitative multiplex analytical method using tandem mass spectrometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7d00ae49f1d86e0b5fd3297c2ed1b8
https://doi.org/10.1021/acs.jafc.7b01018

Base Excision Repair of N6-Deoxyadenosine Adducts of 1,3-Butadiene

Autor: Sheila S. David, Douglas M. Banda, Nicole N. Nuñez, Shaofei Ji, Natalia Y. Tretyakova, Colin R Campbell, Leona D. Samson, Amelia H. Manlove, Bhaskar Malayappan, Susith Wickramaratne

Publikováno v: Biochemistry. 55:6070-6081

The important industrial and environmental carcinogen 1,3-butadiene (BD) forms a range of adenine adducts in DNA, including N6-(2-hydroxy-3-buten-1-yl)-2′-deoxyadenosine (N6-HB-dA), 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4169624eea734114559a4a54d57a8b83
https://doi.org/10.1021/acs.biochem.6b00553

Formation of cyclophosphamide specific DNA adducts in hematological diseases

Autor: Pamala A. Jacobson, Colin R Campbell, Bhaskar Malayappan, Margaret L. MacMillan, Natalia Y. Tretyakova, L'Aurelle A. Johnson, John E. Wagner

Publikováno v: Pediatric Blood & Cancer. 58:708-714

Background Fanconi anemia (FA) patients are hypersensitive to DNA alkylating agents and require lower doses than non-FA patients to minimize serious toxicity. The mechanism by which hypersensitivity occurs is thought to be due to the inability of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::547ad98271e269f97e78f9b6b2a2bcc3
https://doi.org/10.1002/pbc.23254

Cellular Repair of DNA–DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane

Autor: Bhaskar Malayappan, Amanda Degner, Colin R Campbell, Shira Yomtoubian, Lisa N. Chesner, Dewakar Sangaraju, Natalia Y. Tretyakova, Susith Wickramaratne

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 5, p 1086 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 1086

Xenobiotic-induced interstrand DNA–DNA cross-links (ICL) interfere with transcription and replication and can be converted to toxic DNA double strand breaks. In this work, we investigated cellular responses to 1,4-bis-(guan-7-yl)-2,3-butanediol (bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817d0f03693340f8d5cc463c8e1b52dd
https://doi.org/10.3390/ijms18051086

Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress

Autor: Mark S. Segal, Christiaan Leeuwenburgh, Timothy J. Garrett, Bhaskar Malayappan

Publikováno v: Journal of chromatography. A. 1167(1)

A sensitive and specific assay aimed at measuring the oxidized nucleic acids, 8-oxoguanine (8-oxoGua), fapy-guanine (Fapy-Gua), 8-oxoguanosine (8-oxoGuo), 8-oxo-2'-deoxyguanosine (8-oxodG) has been developed by coupling reversed phase liquid chromato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79aa8ff3e21024ee7ac034c0b914764
https://pubmed.ncbi.nlm.nih.gov/17765254