Zobrazeno 1 - 10
of 500
pro vyhledávání: '"Bhaskar Dasgupta"'
Autor:
Wolfgang A. Schmidt, Bhaskar Dasgupta, Jennifer Sloane, Angeliki Giannelou, Yuqing Xu, Sebastian H. Unizony, Sarah L. Mackie, Miguel A. Gonzalez-Gay, Robert Spiera, Kenneth J. Warrington, Peter M. Villiger, Michael C. Nivens, Bolanle Akinlade, Yong Lin, Frank Buttgereit, John H. Stone
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Giant cell arteritis (GCA) is primarily treated with glucocorticoids (GCs), which have substantial toxicity. Tocilizumab, an interleukin-6-receptor inhibitor (IL-6Ri), showed beneficial effects in GCA, leading to its approval. Thi
Externí odkaz:
https://doaj.org/article/4519641ec60d4627b6d5c6d36c1bb6ac
Autor:
Edoardo Conticini, Paolo Falsetti, Suhel Gabriele Al Khayyat, Silvia Grazzini, Caterina Baldi, Francesca Bellisai, Stefano Gentileschi, Marco Bardelli, Claudia Fabiani, Luca Cantarini, Bhaskar Dasgupta, Bruno Frediani
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectivesUltrasound has a paramount role in the diagnostic assessment of giant cell arteritis (GCA); Southend halo score (HS), halo count (HC), and OMERACT GCA Ultrasonography Score (OGUS) are the first quantitative scores proposed in this setting.
Externí odkaz:
https://doaj.org/article/3663c88b4fc644f3a5fb079615d379cf
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
X-ray free-electron laser (XFEL) is the latest generation of the X-ray source that could become an invaluable technique in structural biology. XFEL has ultrashort pulse duration, extreme peak brilliance, and high spatial coherence, which could enable
Externí odkaz:
https://doaj.org/article/2aba616042774daaa47afae806f3fb84
Autor:
Rosanne D. Reitsema, William F. Jiemy, Lieske Wekema, Annemieke M. H. Boots, Peter Heeringa, Minke G. Huitema, Wayel H. Abdulahad, Yannick van Sleen, Maria Sandovici, Caroline Roozendaal, Arjan Diepstra, Thomas Kwee, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis S. M. van der Geest
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundAlthough polymyalgia rheumatica (PMR) is a very common rheumatic inflammatory disease, current insight into the pathobiology of PMR is limited and largely based on studies in blood. We investigated T helper 1 (TH1) and T helper 17 (TH17) ce
Externí odkaz:
https://doaj.org/article/cc4c2e8686df45bdaeca7880ec9daeda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We analyze networks of functional correlations between brain regions to identify changes in their structure caused by Attention Deficit Hyperactivity Disorder (adhd). We express the task for finding changes as a network anomaly detection pro
Externí odkaz:
https://doaj.org/article/d059dd5758ab48b8b4455c31f954b891
Autor:
Wolfgang A. Schmidt, Bhaskar Dasgupta, Raashid Luqmani, Sebastian H. Unizony, Daniel Blockmans, Zhihong Lai, Regina H. Kurrasch, Ivana Lazic, Kurt Brown, Ravi Rao
Publikováno v:
Rheumatology and Therapy, Vol 7, Iss 4, Pp 793-810 (2020)
Abstract Introduction To evaluate the efficacy and safety of sirukumab in giant cell arteritis (GCA). Methods In this multicentre, randomised, double-blind, placebo-controlled, two-part phase 3 trial (NCT02531633; Part A [52-week double-blind treatme
Externí odkaz:
https://doaj.org/article/80874c7e0de648f4bb78c684bf1bc207
Autor:
Alwin Sebastian, Kornelis S. M. van der Geest, Fiona Coath, Prisca Gondo, Abdul Kayani, Craig Mackerness, Bernard Hadebe, Sue Innes, Jo Jackson, Bhaskar Dasgupta
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-10 (2020)
Abstract Background Giant cell arteritis (GCA) is a common large vessel vasculitis of the elderly, often associated with sight loss. Glucocorticoids (GC remain the mainstay of treatment, although biologic treatments have been approved. Biomarkers pre
Externí odkaz:
https://doaj.org/article/364b3073c3cd4f30936e16f893ea2b13
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
ClpB belongs to the cellular disaggretase machinery involved in rescuing misfolded or aggregated proteins during heat or other cellular shocks. The function of this protein relies on the interconversion between different conformations in its native c
Externí odkaz:
https://doaj.org/article/9fc69fcffb994d5493c26ae5c59262bb
Publikováno v:
RMD Open, Vol 6, Iss 3 (2020)
Objectives Clinical presentations of giant cell arteritis (GCA) are protean, and it is vital to make a secure diagnosis and exclude mimics for urgent referrals with suspected GCA. The main objective was to develop a joined-up, end-to-end, fast-track
Externí odkaz:
https://doaj.org/article/3bff2946bdac4c6eb20de86536b6a8f6
Autor:
Bhaskar Dasgupta, Alwin Sebastian, Abdul Kayani, Diana Prieto-Pena, Madeline Whitlock, Jonathan Mo, Niels van der Geest
Publikováno v:
RMD Open, Vol 6, Iss 3 (2020)
Tocilizumab (TCZ), an IL-6 receptor blocker, is approved for relapsing, refractory giant cell arteritis (GCA). We report real-life clinical experience with TCZ in GCA including assessment of responses on imaging (ultrasound (US) and 18F-Fluorodeoxygl
Externí odkaz:
https://doaj.org/article/3c2ff6655b98407db72478393b0e2bbb