Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bhargavi Rajan"'
Autor:
Y. Wang, Jingya Wang, Rebecca Halpin, Bhargavi Rajan, Jeffrey Carrell, Ronald Herbst, Christopher Groves, Yashaswi Shrestha, Christopher Morehouse, R. Rayanki, Roland Kolbeck, Jincheng Wu, R. Grady
Publikováno v:
Blood advances. 2(22)
Long-lived antibody-secreting cells (ASCs) are critical for the maintenance of humoral immunity through the continued production of antibodies specific for previously encountered pathogen or vaccine antigens. Recent reports describing humoral immune
Autor:
Raghavan Venkat, James Savery, Ronald Schoner, Krista Evans, Bhargavi Rajan, Thomas Albanetti, Christopher Groves, Guillermo Miro-Quesada
Publikováno v:
Biotechnology Progress
Regulatory authorities require that cell lines used in commercial production of recombinant proteins must be derived from a single cell progenitor or clone. The limiting dilution method of cell cloning required multiple rounds of low‐density cell p
Autor:
Katie Streicher, Christopher Morehouse, Yihong Yao, Fernanda Pilataxi, Kathleen McKeever, Koustubh Ranade, Ronald Herbst, Philip Brohawn, Brandon W. Higgs, Bahija Jallal, Laura Richman, Kim Lehmann, Steven A. Greenberg, Christopher Groves, David Fiorentino, Bhargavi Rajan
Publikováno v:
Arthritis & Rheumatology. 66:173-184
Objective Production of pathogenic autoantibodies by self-reactive plasma cells (PCs) is a hallmark of autoimmune diseases. We undertook this study to investigate the prevalence of PCs and their relationship to known pathogenic pathways to increase o
Autor:
Rachel Ettinger, Raphaela Goldbach-Mansky, Chris Morehouse, Bonnie Swerdlow, Ronald Herbst, Mildred Wilson, Ying Li, Bhargavi Rajan, Geoffrey L. Stephens, Anthony J. Coyle, Christopher Groves, Fredrick G. Karnell, Jodi L. Karnell
Publikováno v:
The Journal of Immunology. 187:3603-3612
Production of pathogenic Abs contributes to disease progression in many autoimmune disorders. The immunosuppressant agent mycophenolic acid (MPA) has shown clinical efficacy for patients with autoimmunity. The goal of these studies was to elucidate t
Autor:
Erika Farmer, Kamelia Zerrouki, Inna Vainshtein, Meina Liang, Jeffrey M. Riggs, Bhargavi Rajan, Chris Morehouse, Kevin Schifferli, Kimberly Rosenthal, Richard N. Hanna, Divya Sagar, Melissa de los Reyes, Roland Kolbeck, Miguel A. Sanjuan, Gary P. Sims, Jodi L. Karnell
Publikováno v:
Lupus Science & Medicine
Objective We investigated the mechanistic and pharmacological properties of anifrolumab, a fully human, effector-null, anti-type I interferon (IFN) alpha receptor 1 (IFNAR1) monoclonal antibody in development for SLE. Methods IFNAR1 surface expressio
Autor:
Katie, Streicher, Christopher A, Morehouse, Christopher J, Groves, Bhargavi, Rajan, Fernanda, Pilataxi, Kim P, Lehmann, Philip Z, Brohawn, Brandon W, Higgs, Kathleen, McKeever, Steven A, Greenberg, David, Fiorentino, Laura K, Richman, Bahija, Jallal, Ronald, Herbst, Yihong, Yao, Koustubh, Ranade
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 66(1)
Production of pathogenic autoantibodies by self-reactive plasma cells (PCs) is a hallmark of autoimmune diseases. We undertook this study to investigate the prevalence of PCs and their relationship to known pathogenic pathways to increase our underst
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(3)
We have previously shown that B cells (in particular B1 cells) are important in host protection against brugian infections in a murine i.p. model. In this study, we show that mice deficient in circulating IgM (secIgM−/−), but otherwise normal in
Filarial infections evoke exuberant inflammatory responses in the peritoneal cavities of immunocompetent mice. Clearance of infection appears to be dependent on complex interactions between B1 and B2 B lymphocytes, T cells, eosinophils, macrophages,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907132b197cf1fc17336bd364507cbe3
https://europepmc.org/articles/PMC166020/
https://europepmc.org/articles/PMC166020/
Autor:
Y. Wang, Bhargavi Rajan, Christopher Groves, Ronald Herbst, Christopher Morehouse, Rachel Ettinger, R. Rayanki, Yihong Yao
Publikováno v:
Annals of the Rheumatic Diseases. 72:A175.3-A175
Background Plasma cells (PC), are differentiated B cells that play a major role in humoral immunity as they actively secrete antibodies which identify and neutralize foreign antigens. Normally, plasma cells develop in response to immune challenges su
Autor:
Koustubh Ranade, Ronald Herbst, Katie Streicher, David Fiorentino, Steven A. Greenberg, Kathleen McKeever, Christopher Morehouse, Brandon W. Higgs, Bahija Jallal, Yihong Yao, Kim Lehmann, Philip Brohawn, F. Pilataxi, Laura Richman, Christopher Groves, Bhargavi Rajan
Publikováno v:
Annals of the Rheumatic Diseases. 72:A166.1-A166
Background Production of pathogenic autoantibodies by self-reactive plasma cells (PC) is a hallmark of autoimmune diseases; thus, PC levels could be associated with efficacy of B-cell depleting therapies. Additionally, investigating the prevalence of