Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.

Autor: Amard J Abcejo, Venkatachalem Sathish, Dan F Smelter, Bharathi Aravamudan, Michael A Thompson, William R Hartman, Christina M Pabelick, Y S Prakash

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e44343 (2012)

Neurotrophins (NTs), which play an integral role in neuronal development and function, have been found in non-neuronal tissue (including lung), but their role is still under investigation. Recent reports show that NTs such as brain-derived neurotroph

Externí odkaz: https://doaj.org/article/7233ac1f2d704b47afad4a533070d0d8

Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

Autor: Michael A. Thompson, Y. S. Prakash, Gary C. Sieck, Robert Vassallo, Christina M. Pabelick, Bharathi Aravamudan

Publikováno v: Journal of Cellular Physiology. 232:1053-1068

Long-term exposure to cigarette smoke (CS) triggers airway hyperreactivity and remodeling, effects that involve airway smooth muscle (ASM). We previously showed that CS destabilizes the networked morphology of mitochondria in human ASM by regulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090ecb0ff79e08952cf30bed565a31ab
https://doi.org/10.1002/jcp.25508

Mechanisms of BDNF regulation in asthmatic airway smooth muscle

Autor: Michael A. Thompson, Bharathi Aravamudan, Christina M. Pabelick, Y. S. Prakash

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 311(2)

Brain-derived neurotrophic factor (BDNF), a neurotrophin produced by airway smooth muscle (ASM), enhances inflammation effects on airway contractility, supporting the idea that locally produced growth factors influence airway diseases such as asthma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309b6a5256d8d055e7fb8649d8f8496e
https://pubmed.ncbi.nlm.nih.gov/27317689

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Autor: T. S. Davies, Christopher Corrigan, Christina M. Pabelick, Alexander P. P. Lowe, Bharathi Aravamudan, Y. S. Prakash, Wenhan Chang, Polina Yarova, William R. Ford, Michael A. Thompson, Kenneth J. Broadley, Rodney D. Britt, Donald T. Ward, Hirohito Kita, Sun Yung, Jeremy P.T. Ward, Alecia Stewart, Katja Rietdorf, Venkatachalem Sathish, Zakky Cholisoh, Martin Schepelmann, Sarah C. Brennan, Daniela Riccardi, Paul J. Kemp, Emma Jane Kidd, Michelle R Freeman, Mohd Ezuan Bin Khayat

Publikováno v: Yarova, P L, Stewart, A L, Sathish, V, Britt Jr, R D, Thompson, M A, Lowe, A P P, Freeman, M, Aravamudan, B, Kita, H, Brennan, S C, Schepelmann, M, Davies, T, Yung, S, Cholisoh, Z, Kidd, E J, Ford, W R, Broadley, K J, Rietdorf, K, Chang, W, Bin Khayat, M E, Ward, D T, Corrigan, C J, Ward, J P T, Kemp, P J, Pabelick, C M, Prakash, Y S & Riccardi, D 2015, ' Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma ', Science Translational Medicine, vol. 7, no. 284, pp. 284ra60 . https://doi.org/10.1126/scitranslmed.aaa0282

Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as eosinophil cationic protein. Levels of these cations in body fluids correlate with asthma sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8adb765702c379d4eff758efd353ef

Response to letter by Dr. Marc Hershenson (exposure of airway smooth muscle cells to cigarette smoke extract)

Autor: Philippe Delmotte, Christina M. Pabelick, Robert Vassallo, Bharathi Aravamudan, Y. S. Prakash, Gary C. Sieck, Michael A. Thompson

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 307(4)

to the editor: We thank Drs. Hershenson and Chung for their insightful comments regarding our recent paper on mitochondrial fragmentation and dysfunction in human airway smooth muscle (ASM) induced by cigarette smoke extract (CSE) (1). They raise the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2a864660b4b90c5c829b48f3659d54
https://pubmed.ncbi.nlm.nih.gov/25128538