Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Bharath K Mani"'
Autor:
Kripa Shankar, Nathan P. Metzger, Connor Lawrence, Deepali Gupta, Sherri Osborne-Lawrence, Salil Varshney, Omprakash Singh, Corine P. Richard, Alexander N. Zaykov, Rebecca Rolfts, Barent N. DuBois, Diego Perez-Tilve, Bharath K. Mani, Suntrea T.G. Hammer, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101950- (2024)
Objective: The number of individuals affected by metabolic dysfunction associated fatty liver disease [1] is on the rise, yet hormonal contributors to the condition remain incompletely described and only a single FDA-approved treatment is available.
Externí odkaz:
https://doaj.org/article/d718b66ab372463e861b5c868d549a2d
Autor:
Kripa Shankar, Salil Varshney, Deepali Gupta, Bharath K. Mani, Sherri Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Jeffrey M. Zigman
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionRecurrent episodes of insulin-induced hypoglycemia in patients with diabetes mellitus can result in hypoglycemia-associated autonomic failure (HAAF), which is characterized by a compromised response to hypoglycemia by counterregulatory ho
Externí odkaz:
https://doaj.org/article/c2e91af14828475f8d4b0bbd5b8abc10
Autor:
Kripa Shankar, Nathan P. Metzger, Omprakash Singh, Bharath K. Mani, Sherri Osborne-Lawrence, Salil Varshney, Deepali Gupta, Sean B. Ogden, Shota Takemi, Corine P. Richard, Karabi Nandy, Chen Liu, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101327- (2021)
Objective: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases f
Externí odkaz:
https://doaj.org/article/e32018ffecae4cc2938c33deb5f50823
Autor:
Kripa Shankar, Shota Takemi, Deepali Gupta, Salil Varshney, Bharath K. Mani, Sherri Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Eric D. Berglund, Jeffrey M. Zigman
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expr
Externí odkaz:
https://doaj.org/article/365aa24c12284634a2b462dedf7e9fd7
Autor:
Lola J. Torz, Sherri Osborne-Lawrence, Juan Rodriguez, Zhenyan He, María Paula Cornejo, Emilio Román Mustafá, Chunyu Jin, Natalia Petersen, Morten A. Hedegaard, Maja Nybo, Valentina Martínez Damonte, Nathan P. Metzger, Bharath K. Mani, Kevin W. Williams, Jesica Raingo, Mario Perello, Birgitte Holst, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp - (2020)
Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity
Externí odkaz:
https://doaj.org/article/e377e98902394a029b1a044bc11f686a
Autor:
Kripa Shankar, Deepali Gupta, Bharath K. Mani, Brianna G. Findley, Sherri Osborne-Lawrence, Nathan P. Metzger, Chen Liu, Eric D. Berglund, Jeffrey M. Zigman
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Insulin-induced hypoglycemia is a major limiting factor in maintaining optimal blood glucose in patients with type 1 diabetes and advanced type 2 diabetes. Luckily, a counterregulatory response (1) system exists to help minimize and reverse hypoglyce
Externí odkaz:
https://doaj.org/article/877d8692dd534aae86ac24b19a9bd735
Autor:
Bharath K. Mani, Carlos M. Castorena, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Nathan P. Metzger, Joel K. Elmquist, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 114-130 (2018)
Objective: Exercise training has several well-established health benefits, including many related to body weight, appetite control, and blood glucose homeostasis. However, the molecular mechanisms and, in particular, the hormonal systems that mediate
Externí odkaz:
https://doaj.org/article/e9683e627c5b48b9b31841b1b14d3ad4
Autor:
Bharath K. Mani, Sherri Osborne-Lawrence, Mathieu Mequinion, Sydney Lawrence, Laurent Gautron, Zane B. Andrews, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 882-896 (2017)
Objective: Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin r
Externí odkaz:
https://doaj.org/article/9c54f068345946a792313c9e366316f9
Autor:
Aki Uchida, Juliet F. Zechner, Bharath K. Mani, Won-mee Park, Vincent Aguirre, Jeffrey M. Zigman
Publikováno v:
Molecular Metabolism, Vol 3, Iss 7, Pp 717-730 (2014)
The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels we
Externí odkaz:
https://doaj.org/article/7d408b912eaa413c9949224b3825cb9d
Autor:
Martin K Wellman, Zachary Robert Patterson, Harry eMackay, Joseph E Darling, Bharath K Mani, Jeffrey eZigman, James L Hougland, Alfonso eAbizaid
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
Ghrelin is a 28 amino-acid hormonal peptide that is intimately related to the regulation of food intake and body weight. Once secreted, ghrelin binds to the growth hormone secretagogue receptor-1a (GHSR-1a), the only known receptor for ghrelin and is
Externí odkaz:
https://doaj.org/article/11e5bc0126204b67b63d56efa968c4cb