Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bharat V. Kamdar"'
Autor:
Bharat V. Kamdar, William Watt, Mark L. Wolfe, Vincent E. Groppi, Loretta A. Cipkus Dubray, Michael P. Smith, Robert C. Gadwood, Stephen A. Mizsak
Publikováno v:
Journal of Medicinal Chemistry. 36:1480-1487
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of A10 rat aorta cells. This hyperpolarization was blocked by pretreatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57f66c957fa23d8308e33d322ac38c8
https://doi.org/10.1021/jm00062a022
https://doi.org/10.1021/jm00062a022
Autor:
Kevin J Stefanski, Allen E. Buhl, Heinrich J. Schostarez, Bharat V. Kamdar, Marshall N. Brunden, Lisa Marie Thomasco, Garland A. Johnson, Kathy L. Shull, Daniel J. Waldon, Randall G. Stehle, A. R. Diani, Michael J. Mulholland, Theresa M. Schwartz, Steven J. Conrad, Robert C. Gadwood, Marc F. Kubicek
Publikováno v:
Journal of Investigative Dermatology. 98:315-319
The opening of intracellular potassium channels has been suggested as a mechanism regulating hair growth. Enhancing the flux of potassium ions is a mechanism shared by several structurally diverse antihypertensive agents including minoxidil sulfate (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c37d9c08572de8fad1039b8845b74a
https://doi.org/10.1111/1523-1747.ep12499788
https://doi.org/10.1111/1523-1747.ep12499788
Publikováno v:
Journal of Heterocyclic Chemistry. 25:1649-1661
The readily prepared ammonium salt, (CH3)2N+ = CH2Cl−, 4, functionalized heterocycles differently, but in a predictable fashion, under neutral, basic or acidic conditions. Triazolo- and imidazobenzophenones 1b′ and 5, which primarily underwent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58c1d3a32430a1461d45888ad82cfda
https://doi.org/10.1002/jhet.5570250610
https://doi.org/10.1002/jhet.5570250610
Autor:
Patrick J. Delehanty, Bharat V. Kamdar, Piper Richard C, Louis L. Skaletzky, S. C. Perricone, R. E. TenBrink, John M. McCall
Publikováno v:
Journal of Medicinal Chemistry. 29:133-137
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity relationships in this series have been elucidated. Some of the more potent hypotensives wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704464f722ff7476858e96e9a08364a4
https://doi.org/10.1021/jm00151a021
https://doi.org/10.1021/jm00151a021
Autor:
James A. Ruth, Kadim N. Salman, Timothy R. Kroboth, Bharat V. Kamdar, Popat N. Patil, Gary L. Grunewald
Publikováno v:
Journal of Pharmaceutical Sciences. 65:920-923
Four conformationally defined analogs of amphetamine were synthesized and studied for their ability to potentiate the action of levarterenol on the isolated vas deferens from reserpine-treated rats. The compounds also were studied for indirect adrene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bc9ebdec408f63c4cf08c028bce34b
https://doi.org/10.1002/jps.2600650632
https://doi.org/10.1002/jps.2600650632
Autor:
Hossain H. Saneii, Terrence A. Scahill, Bharat V. Kamdar, Donald T. Pals, Clark W. Smith, Tomi K. Sawyer, Judy A. Lawson
Publikováno v:
Journal of Medicinal Chemistry. 31:1377-1382
The synthesis and in vitro renin inhibitory potencies of angiotensinogen (ANG) analogues having amide (CONH) bond replacements at P1-P1', the Leu-Val cleavage site, corresponding to Leu psi[CH2SO]Val, and the trans olefinic analogue of statine (Sta),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8465e8a9a1a229b34708421d69cada95
https://doi.org/10.1021/jm00402a022
https://doi.org/10.1021/jm00402a022
Autor:
Robert Bruce Moffett, Bharat V. Kamdar
Publikováno v:
Journal of Heterocyclic Chemistry. 16:793-797
A number of 5-phenyl-1,4-benzodiazepines and a few 2-phenyl-1,4-benzodiazepines were prepared and screened for central nervous system activity in mice. Some were highly active. An unusual substitution of 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2c02a395434b4cdf600370eb612796
https://doi.org/10.1002/jhet.5570160437
https://doi.org/10.1002/jhet.5570160437
Autor:
Bharat V. Kamdar, Martin Gall
Publikováno v:
The Journal of Organic Chemistry. 46:1575-1585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe5e73e31fc3e576f76464b0e183f5bb
https://doi.org/10.1021/jo00321a010
https://doi.org/10.1021/jo00321a010
Autor:
Robert B. McCall, Bharat V. Kamdar, Douglas W. Harris, Tenbrink Ruth E, S. J. Humphrey, Vimala H. Sethy, John M. McCall, C. Daenzer
Publikováno v:
Journal of medicinal chemistry. 25(1)
A series of 1-[1-(3,4-dimethoxy-1H-2-benzopyran-1-yl)alkyl]-4-arylpiperazines that shows hypotensive activity in the conscious rat has been investigated. Structure-activity relationships are described. A typical example that was investigated in great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9a6b0e16365ae962dca5d56290cdb0
https://pubmed.ncbi.nlm.nih.gov/6123600
https://pubmed.ncbi.nlm.nih.gov/6123600
Autor:
Patrick J. Delehanty, Bharat V. Kamdar, Piper Richard C, R. E. TenBrink, John M. McCall, S. C. Perricone, Louis L. Skaletzky
Publikováno v:
Chemischer Informationsdienst. 17
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity relationships in this series have been elucidated. Some of the more potent hypotensives wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f04b267d53b7cf0b41d8b11f77eb229
https://doi.org/10.1002/chin.198620224
https://doi.org/10.1002/chin.198620224