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pro vyhledávání: '"Bharadwaja Vadloori"'
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Objective Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. With
Externí odkaz:
https://doaj.org/article/f0b6479295e64e3dbc2094a347216d67
Autor:
Akshay Sonawane, Bharadwaja Vadloori, Suresh Poosala, Helena Kandarova, Mandar Kulkarni, Adedamola Olayanju, Tuli Dey, Uday Saxena, Lena Smirnova, Yasunari Kanda, Jaganmohan Reddy, Subhadra Dravida, Saikat Biswas, Mathieu Vinken, Montip Gettayacamin, Arti Ahluwalia, Franco Mondini, Somshuvra Bhattacharya, Pushkar Kulkarni, Kirsten Rosenmay Jacobsen, Subrahmanyam Vangala, Ana Luiza Millás
Publikováno v:
Alternatives to laboratory animals : ATLA. 50(2)
The fact that animal models fail to replicate human disease faithfully is now being widely accepted by researchers across the globe. As a result, they are exploring the use of alternatives to animal models. The time has come to refine our experimenta
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
BMC Research Notes
BMC Research Notes
Objective Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. Withaferin-A
Additional file 1: Figure S1. The structures of ligands: (A) Withaferin-A, (B) Methotrexate, (C) DHFA drawn using Chemdraw ultra version 12.0 software. Figure S2. Sequence identity between Hu DHFR and Ld DHFR-TS. Asterisks indicate identical amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b024bb984a726ebaba7b68e1bf59ba
Akademický článek
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