A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

Autor: El Zawily A; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.; Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa., Vizeacoumar FS; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada., Dahiya R; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada., Banerjee SL; Department of Molecular Biology, Medical Biochemistry and Pathology, PROTEO and Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Division Oncologie, Québec, Canada., Bhanumathy KK; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada., Elhasasna H; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada., Hanover G; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada., Sharpe JC; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada., Sanchez MG; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada., Greidanus P; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada., Stacey RG; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada., Moon KM; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada., Alexandrov I; Biomirex Inc., Natick, Massachusetts., Himanen JP; Department of Biochemistry, University of Turku, Turku, Finland., Nikolov DB; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York., Fonge H; Department of Medical Imaging, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.; Department of Medical Imaging, Royal University Hospital, Saskatoon, Saskatchewan, Canada., White AP; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Health Sciences, Saskatoon, Saskatchewan, Canada.; Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Foster LJ; Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada., Wang B; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, and Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio., Toosi BM; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada., Bisson N; Department of Molecular Biology, Medical Biochemistry and Pathology, PROTEO and Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Division Oncologie, Québec, Canada., Mirzabekov TA; Biomirex Inc., Natick, Massachusetts., Vizeacoumar FJ; Cancer Research, Saskatchewan Cancer Agency and Division of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Freywald A; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jul 14; Vol. 29 (14), pp. 2686-2701.

A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers.

Autor: Elhasasna H; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Khan R; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Bhanumathy KK; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vizeacoumar FS; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Walke P; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, and Cameco MS Neuroscience Research Centre, 701 Queen St., Saskatoon, SK S7K 0M7, Canada., Bautista M; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, and Cameco MS Neuroscience Research Centre, 701 Queen St., Saskatoon, SK S7K 0M7, Canada., Dahiya DK; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Maranda V; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Patel H; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Balagopal A; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Alli N; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Krishnan A; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, and Cameco MS Neuroscience Research Centre, 701 Queen St., Saskatoon, SK S7K 0M7, Canada., Freywald A; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vizeacoumar FJ; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Cancer Research Department, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.

Publikováno v: Cells [Cells] 2022 Jul 20; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 20.

Does AGE-RAGE Stress Play a Role in the Development of Coronary Artery Disease in Obesity?

Autor: Prasad K; Department of Physiology (APP), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Khan AS; Community, Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Bhanumathy KK; Division of Oncology, Cancer Cluster Unit, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Publikováno v: The International journal of angiology : official publication of the International College of Angiology, Inc [Int J Angiol] 2022 Feb 12; Vol. 31 (1), pp. 1-9. Date of Electronic Publication: 2022 Feb 12 (Print Publication: 2022).

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.

Autor: Dong SXM; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Vizeacoumar FS; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Bhanumathy KK; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Alli N; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Gonzalez-Lopez C; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK, Canada., Gajanayaka N; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Caballero R; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Ali H; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Freywald A; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Cassol E; Department of Health Sciences, Carleton University, Ottawa, ON, Canada., Angel JB; Department of Medicine, the Ottawa Health Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Vizeacoumar FJ; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. franco.vizeacoumar@usask.ca.; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK, Canada. franco.vizeacoumar@usask.ca., Kumar A; Apoptosis Research Center, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. akumar@uottawa.ca.; Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. akumar@uottawa.ca.; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. akumar@uottawa.ca.

Publikováno v: BMC infectious diseases [BMC Infect Dis] 2021 Jul 07; Vol. 21 (1), pp. 655. Date of Electronic Publication: 2021 Jul 07.

AGE-RAGE Axis in the Pathophysiology of Chronic Lower Limb Ischemia and a Novel Strategy for Its Treatment.

Autor: Prasad K; Department of Physiology (APP), College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Bhanumathy KK; Division of Oncology, Cancer Cluster Unit, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Publikováno v: The International journal of angiology : official publication of the International College of Angiology, Inc [Int J Angiol] 2020 Sep; Vol. 29 (3), pp. 156-167. Date of Electronic Publication: 2020 May 14.