Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bhanu prasanth Koppolu"'
Autor:
Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram, David A. Zaharoff
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)
Abstract Background Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies a
Externí odkaz:
https://doaj.org/article/3c4716e6a28d4df888466a1360de98b4
Autor:
Julie Eberle Davis, Ravi Kumar Gundampati, Srinivas Jayanthi, Joshua Anderson, Abigail Pickhardt, Bhanu prasanth Koppolu, David A. Zaharoff, Thallapuranam Krishnaswamy Suresh Kumar
Publikováno v:
Biochemistry and Biophysics Reports, Vol 13, Iss , Pp 45-57 (2018)
Acidic human fibroblast growth factor (hFGF1) plays a key role in cell growth and proliferation. Activation of the cell surface FGF receptor is believed to involve the glycosaminoglycan, heparin. However, the exact role of heparin is a subject of con
Externí odkaz:
https://doaj.org/article/8e6c0f7814af4fd0a6fcb6fb12ad3479
Autor:
Srinivas Jayanthi, Bhanu prasanth Koppolu, Khue G. Nguyen, Sean G. Smith, Barbara K. Felber, Thallapuranam Krishnaswamy Suresh Kumar, David A. Zaharoff
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine th
Externí odkaz:
https://doaj.org/article/e144fa0271714f01b788c20adf60ba9f
Publikováno v:
Marine Drugs, Vol 14, Iss 5, p 91 (2016)
Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreac
Externí odkaz:
https://doaj.org/article/152c7e0cd75648aab9d4265b0324a71d
Autor:
Shilpi Agrawal, Gayatri Suresh Kumar, Bhanu prasanth Koppolu, Ravi Kumar Gundampati, David S. McNabb, David A. Zaharoff, Srinivas Jayanthi, Thallapuranam Krishnaswamy Suresh Kumar, Rebecca Kerr, Sanhita Maity
Publikováno v:
Biochemical and biophysical research communications. 518(2)
Acidic fibroblast growth factors (FGF1s) are heparin binding proteins that regulate a wide array of key cellular processes and are also candidates for promising biomedical applications. FGF1-based therapeutic applications are currently limited due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cd9762769a1ec54b6d759cf91f139c
https://pubmed.ncbi.nlm.nih.gov/31420170
https://pubmed.ncbi.nlm.nih.gov/31420170
Autor:
Samantha L. Kurtz, Sruthi Ravindranathan, Bhanu prasanth Koppolu, Haven N. Frazier, Khue G. Nguyen, Sean G. Smith, Narasimhan Rajaram, David A. Zaharoff
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)
Background Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies are unable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f4e899f07ff0b96d9d9f9ad312820c
https://doi.org/10.1186/s13058-018-1054-3
https://doi.org/10.1186/s13058-018-1054-3
Autor:
Srinivas Jayanthi, Thallapuranam Krishnaswamy Suresh Kumar, Vanessa Weidling, Monica Armstrong, Varun Shah, Shilpi Agrawal, Julie Eberle Davis, Arwa Alghanmi, Ellen Fields, Bhanu prasanth Koppolu, David A. Zaharoff, Ravi Kumar Gundampati
Publikováno v:
Archives of biochemistry and biophysics. 654
Human acidic fibroblast growth factor 1 (hFGF1) is a protein intricately involved in cell growth and tissue repair. In this study, we investigate the effect(s) of understanding the role of a conserved proline (P135), located in the heparin binding po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc91ac87b811684fa917bee441516ac9
https://pubmed.ncbi.nlm.nih.gov/30031837
https://pubmed.ncbi.nlm.nih.gov/30031837
Autor:
Sean G. Smith, Barbara K. Felber, David A. Zaharoff, Thallapuranam Krishnaswamy Suresh Kumar, Rashmi Jalah, Margherita Rosati, George N. Pavlakis, Srinivas Jayanthi, Jenifer Bear, Bhanu prasanth Koppolu
Publikováno v:
Protein Expression and Purification. 102:76-84
Interleukin-12 is a heterodimeric, pro-inflammatory cytokine that is a key driver of cell-mediated immu- nity. Clinical interest in IL-12 is significant due to its potent anti-tumor activity and efficacy in controlling certain infectious diseases suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66af9e0c833ec74900bfc73aa0d9102e
https://doi.org/10.1016/j.pep.2014.07.002
https://doi.org/10.1016/j.pep.2014.07.002
Autor:
Matthew D. Katz, Sean G. Smith, David A. Zaharoff, Lirong Yang, Sruthi Ravindranathan, Bhanu prasanth Koppolu, Samantha L. Kurtz
Publikováno v:
Cancer immunology, immunotherapy : CII. 64(6)
Bladder cancer is a highly recurrent disease in need of novel, durable treatment strategies. This study assessed the ability of an intravesical immunotherapy composed of a coformulation of the biopolymer chitosan with interleukin-12 (CS/IL-12) to ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd230d3191232dd801db59eba653b79
https://pubmed.ncbi.nlm.nih.gov/25754122
https://pubmed.ncbi.nlm.nih.gov/25754122
Autor:
Bhanu prasanth Koppolu, Srinivas Jayanthi, Thallapuranam Krishnaswamy Suresh Kumar, Sruthi Ravindranathan, Sean G. Smith, David A. Zaharoff
Publikováno v:
Biomaterials. 35(14)
Chitosan-based nano/microencapsulation is under increasing investigation for the delivery of drugs, biologics and vaccines. Despite widespread interest, the literature lacks a defined methodology to control chitosan particle size and drug/protein rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b675f20cf3898f799f545779e2c405b6
https://pubmed.ncbi.nlm.nih.gov/24560459
https://pubmed.ncbi.nlm.nih.gov/24560459