Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bhanu P. Pappu"'
Autor:
Yongliang Zhang, Joseph M. Reynolds, Yeonseok Chung, Juan Peng, Li Ma, Qiang Tian, Xuexian O. Yang, Bhanu P. Pappu, Gustavo J. Martinez, Chen Dong, Roza Nurieva
Publikováno v:
Immunity. 32:692-702
SummaryToll-like receptors (TLRs) have previously been shown to play critical roles in the activation of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 (Th17) cell responses. Stimulation with TLR2 agonists pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7892ca83dd2ff08cfdd7769e0400775
https://doi.org/10.1016/j.immuni.2010.04.010
https://doi.org/10.1016/j.immuni.2010.04.010
Autor:
Xuexian O. Yang, Suzanne Craig, Athanasia D. Panopoulos, Bhanu P. Pappu, Hong Soon Kang, Yeonseok Chung, Tomohide Yamazaki, Chen Dong, Li Ma, Qiang Tian, Atsushi Fukunaga, Natalia Martin-Orozco, Anton M. Jetten, Stephanie S. Watowich, Roza Nurieva
Publikováno v:
Scopus-Elsevier
Th17 and regulatory T (Treg) cells play opposite roles in autoimmune diseases. However, the mechanisms underlying their proper migration to inflammatory tissues are unclear. In this study, we report that these two T cell subsets both express CCR6. CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a815c2801db3ad2665440299e53cc9a9
https://doi.org/10.4049/jimmunol.181.12.8391
https://doi.org/10.4049/jimmunol.181.12.8391
Autor:
Bhanu P. Pappu, Xuexian O. Yang, Shawn Weng, Ping Wu, Qiang Tian, Richard A. Flavell, Beth Browning, Timothy S. Zheng, Xingwen Dong, Martin L. Scott, Lihe Su, Chen Dong, Li Ma, Linda C. Burkly, Anna Borodovsky, Pascal Schneider
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 205, no. 5, pp. 1049-1062
Journal of Experimental Medicine, vol. 205, no. 5, pp. 1049-1062
T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not well understood. We show that the expression of a tumor necrosis factor receptor family member, death receptor 3 (DR3; also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f07c5c076f32085063366f90e0c6143
https://doi.org/10.1084/jem.20071364
https://doi.org/10.1084/jem.20071364
Autor:
Xin Lin, Demin Wang, Stephan W. Morris, Bhanu P. Pappu, Liquan Xue, Hu Zeng, Renren Wen, Yuhong Chen
Publikováno v:
The Journal of Immunology. 178:49-57
The adaptor protein B cell lymphoma 10 (Bcl10) plays an essential role in the functions of the AgRs in T and B cells. In this study, we report that Bcl10 also plays an important role in mast cells. Bcl10 is expressed in mast cells. Although Bcl10-def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d028da43376eede6d2fbb415fb33b9e1
https://doi.org/10.4049/jimmunol.178.1.49
https://doi.org/10.4049/jimmunol.178.1.49
Autor:
Xin Lin, Bhanu P. Pappu
Publikováno v:
European Journal of Immunology. 36:3033-3043
NF-kappaB activation through B cell receptor (BCR) ligation is critical for B cell development, survival and antigen-mediated activation of B cells. CARD domain and MAGUK-domain containing protein-1 (CARMA1), recently identified adaptor molecule, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26899976ecea601d394899ce7b6ed004
https://doi.org/10.1002/eji.200535663
https://doi.org/10.1002/eji.200535663
Autor:
Bhanu P. Pappu, Hongxiu Li, Xin Lin, Reiko Matsumoto, Donghai Wang, Masayuki Kobayashi, Marzenna Blonska, Demin Wang, Yuhong Chen
Publikováno v:
Immunity. 23(6):575-585
Summary CARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CARMA1 in the signaling pathway is not clear. Here, we show that CARMA1 is inducibly phosphorylated after TCR-CD28 costimulation. This phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9274b33cebb593fd1424944d47f0b407
Autor:
Chen Dong, Bhanu P. Pappu
Publikováno v:
Current Protocols in Immunology
Upon antigenic stimulation, naive CD4+ T cells undergo proliferation and differentiate into cytokine-producing T helper (T(H)) effector cells. T(H)1 cells secrete effector cytokine IFN-gamma and regulate cell-mediated immunity, whereas T(H)2 cells pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec410a92f5a207b4b72d3bb8039cffb2
https://pubmed.ncbi.nlm.nih.gov/18432994
https://pubmed.ncbi.nlm.nih.gov/18432994
Publikováno v:
Pharmacologytherapeutics. 117(3)
Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f608cc5ac1819b8378302eedfd5a956
https://pubmed.ncbi.nlm.nih.gov/18280574
https://pubmed.ncbi.nlm.nih.gov/18280574
Autor:
Bhanu P. Pappu, Hiroaki Sakurai, Hongxiu Li, Xin Lin, Yun You, Bryant G. Darnay, Josef M. Penninger, Prashant Shambharkar, Hiromitsu Hara, Marzenna Blonska
Publikováno v:
The EMBO journal. 26(7)
The IkappaB kinase (IKK) complex serves as the master regulator for the activation of NF-kappaB by various stimuli. It contains two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma/NEMO. The activation of IKK complex is de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e1aa3c68e60c2c4776cdfb159d1019
https://pubmed.ncbi.nlm.nih.gov/17363905
https://pubmed.ncbi.nlm.nih.gov/17363905
Publikováno v:
Immunity. 26(1)
SummaryMembers of the c-Jun NH2-terminal kinase (JNK) family play crucial roles in cell activation, differentiation, and apoptosis. Although many studies have indicated that JNK1 and JNK2 have functional differences and redundancy, the upstream signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e199db497755b0b552eed5b8b06ff3
https://pubmed.ncbi.nlm.nih.gov/17189706
https://pubmed.ncbi.nlm.nih.gov/17189706