Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

Autor: Jesús Cadenas, Susanne Elisabeth Pors, Ajay Kumar, Bhanu Kalra, Stine Gry Kristensen, Claus Yding Andersen, Linn Salto Mamsen

Publikováno v: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-10 (2022)

Abstract Background The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant proteins, and little is known about native GDF9 and BMP15 in humans. Methods Human immature cumulus

Externí odkaz: https://doaj.org/article/e7c5ae17be5e45ac96f9a2b0e8b37239

High Variability of Molecular Isoforms of AMH in Follicular Fluid and Granulosa Cells From Human Small Antral Follicles

Autor: Linn Salto Mamsen, Jane Alrø Bøtkjær, Stine Gry Kristensen, Susanne Elisabeth Pors, Janni Vikkelsø Jeppesen, Ajay Kumar, Bhanu Kalra, Erik Ernst, Claus Yding Andersen

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily produced by follicular granulosa cells (GCs) in women from late gestation to the end of reproductive life. AMH is thought to inhibit aromatase (i.e., CYP19) expression and decrease t

Externí odkaz: https://doaj.org/article/9df4a2706c224d1fba42a49f697b93ab

PAPP‐A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia

Autor: Rugina I. Neuman, Maaike M. Alblas van der Meer, Daan Nieboer, Langeza Saleh, Koen Verdonk, Bhanu Kalra, Ajay Kumar, Kannan Alpadi, Anton H. van den Meiracker, Willy Visser, A. H. Jan Danser

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)

Background We aimed to evaluate the value of inhibin A and PAPP‐A2 (pregnancy‐associated plasma protein‐A2) as novel biomarkers in the prediction of preeclampsia‐related complications and how they compare with angiogenic biomarkers. Methods a

Externí odkaz: https://doaj.org/article/b5a0184635514c1f84fefd317120edcc

Circulating levels of proglucagon‐derived peptides are differentially regulated by the glucagon‐like peptide‐1 agonist liraglutide and the centrally acting naltrexone/bupropion and can predict future weight loss and metabolic improvements: A 6‐month long interventional study

Autor: Konstantinos Stefanakis, Alexander Kokkinos, Georgia Argyrakopoulou, Sofia K. Konstantinidou, Stamatia Simati, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Melina Kumar, Nikolaos Bontozoglou, Konstantina Kyriakopoulou, Christos S. Mantzoros

Publikováno v: Diabetes, Obesity and Metabolism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d19fa48b352261583c824fd6beaf0f7
https://doi.org/10.1111/dom.15141

Intrafollicular Concentrations of the Oocyte-secreted Factors GDF9 and BMP15 Vary Inversely in Polycystic Ovaries

Autor: Stine Gry Kristensen, Ajay Kumar, Linn Salto Mamsen, Bhanu Kalra, Susanne Elisabeth Pors, Jane Alrø Bøtkjær, Kirsten Tryde Macklon, Jens Fedder, Erik Ernst, Kate Hardy, Stephen Franks, Claus Yding Andersen

Publikováno v: E3383
E3374
Kristensen, S G, Kumar, A, Mamsen, L S, Kalra, B, Pors, S E, Bøtkjær, J A, Macklon, K T, Fedder, J, Ernst, E, Hardy, K, Franks, S & Andersen, C Y 2022, ' Intrafollicular Concentrations of the Oocyte-secreted Factors GDF9 and BMP15 Vary Inversely in Polycystic Ovaries ', The Journal of Clinical Endocrinology & Metabolism, vol. 107, no. 8, pp. e3374-e3383 . https://doi.org/10.1210/clinem/dgac272
Kristensen, S G, Kumar, A, Mamsen, L S, Kalra, B, Pors, S E, Bøtkjær, J A, Macklon, K T, Fedder, J, Ernst, E, Hardy, K, Franks, S & Andersen, C Y 2022, ' Intrafollicular Concentrations of the Oocytesecreted Factors GDF9 and BMP15 Vary Inversely in Polycystic Ovaries ', Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 8, pp. E3374-E3383 . https://doi.org/10.1210/clinem/dgac272

Context The oocyte-secreted factors growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) play essential roles in follicle development and oocyte maturation, and aberrant regulation might contribute to the pathogenesis of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b977d4cedec2e54f5ca12fcb36babf63
https://doi.org/10.1210/clinem/dgac272