Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Bhalchandra V, Joshi"'
Autor:
Pedro, Besada, Liaman K, Mamedova, Krishnan K, Palaniappan, Zhan-Guo, Gao, Bhalchandra V, Joshi, Lak Shin, Jeong, Mortimer M, Civan, Kenneth A, Jacobson
Publikováno v:
Collect Czechoslov Chem Commun
9-(β-D-Ribosfuranosyluronamide)adenine derivatives that are selective agonists and antagonists of the A(3) adenosine receptor (AR) have been derivatized as prodrugs for in vivo delivery. The free hydroxy groups at the 2′ and 3′ positions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd9d3c2ff672a05d61b036feba86fbed
https://pubmed.ncbi.nlm.nih.gov/34815583
https://pubmed.ncbi.nlm.nih.gov/34815583
Publikováno v:
Annual reports in medicinal chemistry. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92f0a94616fd1c1a304ff3300f8e8490
https://pubmed.ncbi.nlm.nih.gov/26640305
https://pubmed.ncbi.nlm.nih.gov/26640305
Autor:
Kim Peterson-Yantorno, Zhan Guo Gao, Kenneth A. Jacobson, Lak Shin Jeong, Pedro Besada, Marcel Y. Avila, Zhao Wang, Richard A. Stone, Bhalchandra V. Joshi, Mortimer M. Civan, Chi Wai Do
Publikováno v:
Experimental Eye Research. 90:146-154
The purpose of the study was to determine whether novel, selective antagonists of human A 3 adenosine receptors (ARs) derived from the A 3 -selective agonist Cl-IB-MECA lower intraocular pressure (IOP) and act across species. IOP was measured invasiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67732500de369de08dc10411f7db9ec8
https://doi.org/10.1016/j.exer.2009.10.001
https://doi.org/10.1016/j.exer.2009.10.001
Autor:
Yixing Zhou, Artem Melman, T. Kendall Harden, Jan Hajduch, Bhalchandra V. Joshi, Pavol Kováč, Arijit Das, Hyojin Ko, Andrei A. Ivanov, Kenneth A. Jacobson, Kenneth L. Kirk, Ingrid P. Fricks, Rhonda L. Carter
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:5298-5311
The P2Y(14) receptor, a nucleotide signaling protein, is activated by uridine-5'-diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9ce49d86db4901d4751cece50637f2
https://doi.org/10.1016/j.bmc.2009.05.024
https://doi.org/10.1016/j.bmc.2009.05.024
Autor:
Abesh Kumar Bhattacharjee, Lixin Lang, Sonia de Castro, Ying Ma, Zhan-Guo Gao, Bhalchandra V. Joshi, Dale O. Kiesewetter, Kenneth A. Jacobson, Artem Melman
Publikováno v:
Nuclear Medicine and Biology. 36:3-10
Introduction Bromine-76-radiolabeled analogues of previously reported high-affinity A 3 adenosine receptor (A 3 AR) nucleoside ligands have been prepared as potential radiotracers for positron emission tomography. Methods The radiosyntheses were acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595e885e2cc5788901c3d3fb7b5e516a
https://doi.org/10.1016/j.nucmedbio.2008.10.003
https://doi.org/10.1016/j.nucmedbio.2008.10.003
Autor:
Zhan-Guo Gao, Ben Wang, Sonia de Castro, Soo-Kyung Kim, Kenneth A. Jacobson, Lak Shin Jeong, Cara L. Heller, Bhalchandra V. Joshi, Artem Melman
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:8546-8556
We have prepared 5′-modified derivatives of adenosine and a corresponding (N)-methanocarba nucleoside series containing a bicyclo[3.1.0]hexane ring system in place of the ribose moiety. The compounds were examined in binding assays at three subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3890c331216a62303a681163bd82f46
https://doi.org/10.1016/j.bmc.2008.08.007
https://doi.org/10.1016/j.bmc.2008.08.007
Autor:
Sara Bar-Yehuda, Kenneth A. Jacobson, P. Fishman, Avivit Ochaion, G. Perez-Liz, Faina Barer, Zhan-Guo Gao, Bhalchandra V. Joshi, Shira Cohen, Howard Amital, R. Patoka, L. Del Valle
Publikováno v:
Biochemical Pharmacology. 76:482-494
The A(3) adenosine receptor (A(3)AR) is over-expressed in inflammatory cells and was defined as a target to combat inflammation. Synthetic agonists to this receptor, such as IB-MECA and Cl-IB-MECA, exert an anti-inflammatory effect in experimental an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043a7fc57619815ab2e1aca4964d41fc
https://doi.org/10.1016/j.bcp.2008.05.032
https://doi.org/10.1016/j.bcp.2008.05.032
Autor:
Wangzhong Chen, Kenneth A. Jacobson, Lak Shin Jeong, Bhalchandra V. Joshi, Yong-Chul Kim, Ga Eun Lee, Hyung Ryong Moon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:571-575
Analogues of the P2X 7 receptor antagonist KN-62, modified at the piperazine and arylsulfonyl groups, were synthesized and assayed at the human P2X 7 receptor for inhibition of BzATP-induced effects, that is, uptake of a fluorescent dye (ethidium bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712e31984d420354027fd3dc3dac1559
https://doi.org/10.1016/j.bmcl.2007.11.077
https://doi.org/10.1016/j.bmcl.2007.11.077
Autor:
Pedro Besada, Bhalchandra V. Joshi, Zhan-Guo Gao, Mortimer M. Civan, Kenneth A. Jacobson, Lak Shin Jeong, Liaman K. Mamedova, Krishnan K. Palaniappan
Publikováno v:
Collection of Czechoslovak Chemical Communications. 71:912-928
9-(β-D-Ribosfuranosyluronamide)adenine derivatives that are selective agonists and antagonists of the A3 adenosine receptor (AR) have been derivatized as prodrugs for in vivo delivery. The free hydroxy groups at the 2' and 3' positions of the agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f9e4117b91e44778f73d19f069c830
https://doi.org/10.1135/cccc20060912
https://doi.org/10.1135/cccc20060912
Autor:
Bhalchandra V. Joshi, Heng T. Duong, Dmitry Sonin, Zhan-Guo Gao, Bruce T. Liang, Susanna Tchilibon, Kenneth A. Jacobson
Publikováno v:
Journal of Medicinal Chemistry. 48:8103-8107
Ring-constrained adenosine analogues have been designed to act as dual agonists at tissue-protective A(1) and A(3) adenosine receptors (ARs). 9-Ribosides transformed into the ring-constrained (N)-methanocarba-2-chloro-5'-uronamides consistently lost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05054956f39b1cc70bd362b390361b57
https://doi.org/10.1021/jm050726b
https://doi.org/10.1021/jm050726b