Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Bhalchandra A. Diwan"'
Publikováno v:
Toxicology Letters. 209:179-185
Inorganic arsenic, an early life carcinogen in humans and mice, can initiate lesions promotable by other agents in later life. The biomethylation product of arsenic, dimethylarsinic acid (DMA), is a multi-site tumor promoter. Thus, pregnant CD1 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435a668127ed93e7f5cd19f3587b936
https://doi.org/10.1016/j.toxlet.2011.12.016
https://doi.org/10.1016/j.toxlet.2011.12.016
Autor:
Konstantin Salnikow, Bhalchandra A. Diwan, Monika Kaczmarek, Kazimierz S. Kasprzak, Mathew J. Fivash, Daniel Logsdon
Publikováno v:
Toxicology and Applied Pharmacology. 257:32-37
The aim of this study was to test a hypothesis that ascorbate depletion could enhance carcinogenicity and acute toxicity of nickel. Homozygous L-gulono--lactone oxidase gene knock-out mice (Gulo-/- mice) unable to produce ascorbate and wild-type C57B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2532b5fec6a79e9d861272cb4fe59d
https://doi.org/10.1016/j.taap.2011.08.015
https://doi.org/10.1016/j.taap.2011.08.015
Publikováno v:
Toxicological Sciences. 119:73-83
In a previously developed mouse model, arsenic exposure in utero induces tumors at multiple sites in the offspring as adults, often duplicating human targets. However, human environmental inorganic arsenic exposure occurs during the entire life span,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc013d02d9757e65f3fca592eca79eb
https://doi.org/10.1093/toxsci/kfq315
https://doi.org/10.1093/toxsci/kfq315
Publikováno v:
Int J Toxicol
To expand our knowledge on the transplacental carcinogenic potential of inorganic arsenic, pregnant Tg.AC mice received drinking water with 0, 42.5, or 85 ppm arsenite from gestation day 8 to 18. After birth, groups (n = 25) of offspring received top
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6262dc93a02da17344cada611b2664e0
https://doi.org/10.1177/1091581810362804
https://doi.org/10.1177/1091581810362804
Arsenic Exposure Transforms Human Epithelial Stem/Progenitor Cells into a Cancer Stem-like Phenotype
Publikováno v:
Environmental Health Perspectives
Background Inorganic arsenic is a ubiquitous environmental carcinogen affecting millions of people worldwide. Evolving theory predicts that normal stem cells (NSCs) are transformed into cancer stem cells (CSCs) that then drive oncogenesis. In humans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788c0aa04ef9fe6253c599eee97ecefa
https://doi.org/10.1289/ehp.0901059
https://doi.org/10.1289/ehp.0901059
Autor:
Gail M. Nelson, Kirk T. Kitchin, Gene J. Ahlborn, James W. Allen, Hongzu Ren, Bhalchandra A. Diwan, J. Christopher Corton, Geremy Knapp, Don A. Delker, Michael P. Waalkes
Publikováno v:
Toxicology
Exposure of male C3H mice in utero (from gestational days 8–18) to 85 ppm sodium arsenite via the dams’ drinking water has previously been shown to increase liver tumor incidence by 2 years of age. However, in our companion study (Ahlborn et al.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6cc82d323ff40e126e0cb8a3987ee3
https://doi.org/10.1016/j.tox.2009.10.004
https://doi.org/10.1016/j.tox.2009.10.004
Autor:
Bhalchandra A. Diwan, Steven P. Donald, James M. Phang, Gregory L. Borchert, Yongmin Liu, Miriam R. Anver
Publikováno v:
Cancer Research. 69:6414-6422
Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves as the main source of energy, proline, an alternative substrate, is important, especially du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780781ca9dc0f6ea2a2016eadb185f9f
https://doi.org/10.1158/0008-5472.can-09-1223
https://doi.org/10.1158/0008-5472.can-09-1223
Publikováno v:
Toxicology and Applied Pharmacology. 238:215-220
The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein called metallothionein (MT) in Cd toxicology. MT plays minimal roles in the gastrointestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40395dfbeb202a579a36517dcfbf576b
https://doi.org/10.1016/j.taap.2009.03.026
https://doi.org/10.1016/j.taap.2009.03.026
Autor:
Miriam R. Anver, M A Sipowicz, Bhalchandra A. Diwan, Lucy M. Anderson, Kazimierz S. Kasprzak, Daniel Logsdon, Peter L. Gorelick
Publikováno v:
Environmental Health Perspectives
Background Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria. Objectives We test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eaaa856348b2c5ea98f8820db150af
https://doi.org/10.1289/ehp.11493
https://doi.org/10.1289/ehp.11493
Autor:
Bhalchandra A. Diwan, Yang Sun, Jie Liu, Miroslav Styblo, Jingbo Pi, Michael P. Waalkes, Yu-Ying He, Wei Qu
Publikováno v:
Free Radical Biology and Medicine. 45:651-658
Arsenic is a well-known human skin carcinogen but the underlying mechanisms of carcinogenesis are unclear. Transcription factor Nrf2-mediated antioxidant response represents a critical cellular defense mechanism, and emerging data suggest that consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40e903f57eadaeb7c1f318f8ccbe5fb
https://doi.org/10.1016/j.freeradbiomed.2008.05.020
https://doi.org/10.1016/j.freeradbiomed.2008.05.020