Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Bhakti, Dwivedi"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Resistance to radiotherapy is a major barrier during cancer treatment. Here using genome-scale CRISPR/Cas9 screening, we identify CD274 gene, which encodes PD-L1, to confer lung cancer cell resistance to ionizing radiation (IR). Depletion of
Externí odkaz:
https://doaj.org/article/0b289724e1b44bbcb80ea46562b400e9
Autor:
Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Ide
Externí odkaz:
https://doaj.org/article/0c944d44150c49a0b8aca89a9d8db85d
Autor:
Hope Mumme, Beena E. Thomas, Swati S. Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Pruthvi Perumalla, Debasree Sarkar, Gulay B. Ulukaya, Himalee S. Sabnis, Sunita I. Park, Deborah DeRyckere, Sunil S. Raikar, Melinda Pauly, Ryan J. Summers, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx),
Externí odkaz:
https://doaj.org/article/a3787863b5cb43ff9dcb50ae8a436b4d
Autor:
Nabil F Saba, Ashok R Dinasarapu, Kelly R Magliocca, Bhakti Dwivedi, Sandra Seby, Zhaohui S Qin, Mihir Patel, Christopher C Griffith, Xu Wang, Mark El-Deiry, Conor Ernst Steuer, Jeanne Kowalski, Dong Moon Shin, Michael E Zwick, Zhuo Georgia Chen
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308819 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0238497.].
Externí odkaz:
https://doaj.org/article/4891af96898b47af897682d1b81bbd2c
Autor:
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL
Externí odkaz:
https://doaj.org/article/2dbae7c4d3ee43d79487bfe5ab1bc1e6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The genomics data-driven identification of gene signatures and pathways has been routinely explored for predicting cancer survival and making decisions related to targeted treatments. A large number of packages and tools have been developed
Externí odkaz:
https://doaj.org/article/10106d5d7b8c4b51a59d15d7dbd0978c
Autor:
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sîrbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Diabetic foot ulcers (DFUs) remain a complication of diabetes that are difficult to heal and lead to disability. Here the authors use single-cell RNA-sequencing and spatial transcriptomics to characterize the DFU cellular landscape and identify a pop
Externí odkaz:
https://doaj.org/article/f9eeb6aeee15457486ee4ea3a39b9697
Autor:
Briana Rackley, Chang-Soo Seong, Evan Kiely, Rebecca E. Parker, Manali Rupji, Bhakti Dwivedi, John M. Heddleston, William Giang, Neil Anthony, Teng-Leong Chew, Melissa Gilbert-Ross
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to t
Externí odkaz:
https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
Autor:
Ju Young Kim, Dong Hun Lee, Joo Kyung Kim, Hong Seo Choi, Bhakti Dwivedi, Manali Rupji, Jeanne Kowalski, Stefan J. Green, Heesang Song, Won Jong Park, Ji Young Chang, Tae Min Kim, Changwon Park
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-9 (2019)
Abstract Previous studies including ours have demonstrated a critical function of the transcription factor ETV2 (ets variant 2; also known as ER71) in determining the fate of cardiovascular lineage development. However, the underlying mechanisms of E
Externí odkaz:
https://doaj.org/article/eb7e411c210d4eb59aa3d1d1a430a5dc
Autor:
Benjamin I Siegel, Tricia Z King, Manali Rupji, Bhakti Dwivedi, Alexis B Carter, Jeanne Kowalski, Tobey J MacDonald
Publikováno v:
Translational Oncology, Vol 12, Iss 7, Pp 908-916 (2019)
Host genome analysis is a promising source of predictive information for long-term morbidity in cancer survivors. However, studies on genetic predictors of long-term outcome, particularly neurocognitive function following chemoradiation in pediatric
Externí odkaz:
https://doaj.org/article/5249a9fec3484d04ab73812c2d6e6b73