Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bhagyesh R. Sarode"'
Publikováno v:
ChemBioChem. 23
Caged morpholino oligonucleotides (cMOs) are synthetic tools that allow light-inducible gene silencing in live organisms. Previously reported cMOs have utilized hairpin, duplex, and cyclic structures, as well as caged nucleobases. While these antisen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34790820ddcc8cbb24714a839225e21c
https://doi.org/10.1002/cbic.202200374
https://doi.org/10.1002/cbic.202200374
Publikováno v:
Molecular Pharmaceutics. 16:4677-4687
In this work we describe the synthesis, characterization and ultimate in-vivo assessment of second generation insulin photoactivated depot (PAD) materials. These are the first to use visible light to stimulate insulin release, and have in-vivo perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf9d00ee3c872846d9851479de23fb8
https://doi.org/10.1021/acs.molpharmaceut.9b00806
https://doi.org/10.1021/acs.molpharmaceut.9b00806
Publikováno v:
Molecular Pharmaceutics. 16:2922-2928
We have previously described the photoactivated depot (PAD) approach for the light-stimulated release of therapeutic proteins such as insulin. The aim of this method is to release insulin from a shallow dermal depot in response to blood glucose infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6704d084717c6078fd60d4bf665c91
https://doi.org/10.1021/acs.molpharmaceut.9b00140
https://doi.org/10.1021/acs.molpharmaceut.9b00140
Publikováno v:
Methods in enzymology. 624
In this work we describe methods for synthesizing and incorporating a wide range of photocleavable groups into proteins. These are based on the di-methoxyl nitro phenyl ethyl (DMNPE) group. Using a common ketone starting material, we have modified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337c9f838186344fab23d906cd2b4e05
https://pubmed.ncbi.nlm.nih.gov/31370926
https://pubmed.ncbi.nlm.nih.gov/31370926
Publikováno v:
Molecular Pharmaceutics
In this work we demonstrate that blood glucose can be controlled remotely through light stimulated release of insulin from an injected cutaneous depot. Human insulin was tethered to an insoluble but injectable polymer via a linker, which was based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f60a7c5f41dad0d99777934dd6ca25a
https://doi.org/10.1021/acs.molpharmaceut.6b00633
https://doi.org/10.1021/acs.molpharmaceut.6b00633
Publikováno v:
Macromolecular Bioscience. 16:1138-1146
The use of light sensitive polymers for the release of therapeutics is an important approach allowing the timing and amount of the release to be controlled precisely. We have pioneered the use of light to control insulin release from a dermal photoac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f552192361b5115ba9130e231c75e0
https://doi.org/10.1002/mabi.201500471
https://doi.org/10.1002/mabi.201500471
Publikováno v:
Macromolecular bioscience. 16(8)
Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717b4df2fd59663cc84a9db4a8d9ccfd
https://pubmed.ncbi.nlm.nih.gov/27491330
https://pubmed.ncbi.nlm.nih.gov/27491330