Genetic modification of T-cell clones for therapy of human viral and malignant diseases

Autor: Pd, Greenberg, Rj, Finch, Ma, Gavin, Kalos M, Da, Lewinsohn, Lonergan M, Jd, Lord, Bh, Nelson, Ohlén C, Ap, Sing, Edus Warren, Yee C, Sr, Riddell

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6015a874bb86ac1ad3abb649db96cdb0
http://europepmc.org/abstract/med/9619278

Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer.

Autor: Nelson BH; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Hamilton P; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Phung MT; School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Milne K; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Harris B; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Thornton S; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Stevens D; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Kalaria S; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada., Singh K; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Laumont CM; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Moss E; Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada., Alimujiang A; School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Meagher NS; School of Clinical Medicine, University of New South Wales (NSW) Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia., Bolithon A; School of Clinical Medicine, University of New South Wales (NSW) Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia., Fereday S; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Kennedy CJ; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Hendley J; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Ariyaratne D; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Alsop K; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Traficante N; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia., Goode EL; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Karnezis A; Department of Pathology, University of California Davis School of Medicine, Sacramento, California, USA., Shen H; Van Andel Institute, Grand Rapids, Michigan, USA., Richardson J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Patient advocate., McKinnonDeurloo C; Patient advocate., Chase A; Patient advocate., Grout B; Patient advocate., Doherty JA; Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA., Harris HR; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Cushing-Haugen KL; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Anglesio M; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, British Columbia, Canada., Heinze K; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, British Columbia, Canada., Huntsman D; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada., Talhouk A; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, British Columbia, Canada., Hanley GE; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia's Gynecological Cancer Research Team (OVCARE), University of British Columbia, BC Cancer, and Vancouver General Hospital, Vancouver, British Columbia, Canada., Alsop J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Jimenez-Linan M; Department of Histopathology, Addenbrooke's Hospital, Cambridge, United Kingdom., Pharoah PD; Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, California, USA., Boros J; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Brand AH; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Harnett PR; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Crown Princess Mary Cancer Centre and., Sharma R; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Westmead Hospital, Sydney, New South Wales, Australia.; Western Sydney University, Sydney, New South Wales, Australia., Hecht JL; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA., Sasamoto N; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Terry KL; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Karlan B; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California, USA., Lester J; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California, USA., Carney ME; Department of Obstetrics and Gynecology, John A. Burns School of Medicine University of Hawaii, Honolulu, Hawaii, USA., Goodman MT; Cancer Prevention and Control Program, Cedars-Sinai Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California, USA., Hernandez BY; University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Wilkens LR; University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Behrens S; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Turzanski Fortner R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Research, Cancer Registry of Norway, Oslo, Norway., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany., Bisinotto C; Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Candido Dos Reis FJ; Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Ghatage P; Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Köbel M; Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada., Elishaev E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Modugno F; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Women's Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Cook L; Epidemiology, School of Public Health, University of Colorado, Aurora, Colorado, USA.; Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., Le N; Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada., Gentry-Maharaj A; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology and.; Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom., Menon U; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology and., García MJ; Cancer Biology Department, Sols-Morreale Biomedical Research Institute (IIBM), CSIC UAM, Madrid, Spain., Rodriguez-Antona C; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Farrington K; Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada., Kelemen LE; Division of Acute Disease Epidemiology, South Carolina Department of Health and Environmental Control, Columbia, South Carolina, USA., Kommoss S; Department of Women's Health and., Staebler A; Institute of Pathology and Neuropathology, Tuebingen University Hospital, Tuebingen, Germany., Garsed DW; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., Brenton JD; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Piskorz AM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Bowtell DD; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia., DeFazio A; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Ramus SJ; School of Clinical Medicine, University of New South Wales (NSW) Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia., Pike MC; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Pearce CL; School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Oct 29; Vol. 134 (24). Date of Electronic Publication: 2024 Oct 29.

Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma.

Autor: Sarkozy C, Wu S, Takata K, Aoki T, Neriah SB, Milne K, Goodyear T, Strong C, Rastogi T, Hilton LK, Lai D, Sehn LH, Farinha P, Nelson BH, Weng A, Marra M, Scott DW, Craig JW, Steidl C, Roth A

Publikováno v: Cancer cell [Cancer Cell] 2024 Sep 09; Vol. 42 (9), pp. 1630. Date of Electronic Publication: 2024 Aug 15.

VOLTA: an enVironment-aware cOntrastive ceLl represenTation leArning for histopathology.

Autor: Nakhli R; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Rich K; Bioinformatics Graduate Program, University of British Columbia, Vancouver, Canada., Zhang A; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Darbandsari A; Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada., Shenasa E; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Hadjifaradji A; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Thiessen S; Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada., Milne K; Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada., Jones SJM; Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, Canada., McAlpine JN; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada., Nelson BH; Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada., Gilks CB; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Farahani H; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Bashashati A; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada. ali.bashashati@ubc.ca.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. ali.bashashati@ubc.ca.; Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, Canada. ali.bashashati@ubc.ca.

Publikováno v: Nature communications [Nat Commun] 2024 May 10; Vol. 15 (1), pp. 3942. Date of Electronic Publication: 2024 May 10.

Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22.

Autor: McComb S; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada., Arbabi-Ghahroudi M; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Hay KA; Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada.; Division of Hematology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Keller BA; Division of Anatomical Pathology, The Ottawa Hospital/University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Faculty of Medicine, Ottawa, ON, Canada., Faulkes S; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Rutherford M; Division of Anatomical Pathology, The Ottawa Hospital/University of Ottawa, Ottawa, ON, Canada.; Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital/University of Ottawa, Ottawa, ON, Canada., Nguyen T; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Shepherd A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Wu C; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.; Department of Biology, Concordia University, Montréal, QC, Canada., Marcil A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Aubry A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Hussack G; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Pinto DM; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Ryan S; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Raphael S; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., van Faassen H; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Zafer A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Zhu Q; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Maclean S; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Chattopadhyay A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Gurnani K; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Gilbert R; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Gadoury C; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Iqbal U; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Fatehi D; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Jezierski A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Huang J; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Pon RA; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Sigrist M; Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada., Holt RA; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.; Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Nelson BH; Deeley Research Centre, British Columbia Cancer Research Institute, Victoria, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Atkins H; Division of Hematology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Kekre N; Division of Hematology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Yung E; Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada., Webb J; Deeley Research Centre, British Columbia Cancer Research Institute, Victoria, BC, Canada., Nielsen JS; Deeley Research Centre, British Columbia Cancer Research Institute, Victoria, BC, Canada., Weeratna RD; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.

Publikováno v: Molecular therapy. Oncology [Mol Ther Oncol] 2024 Feb 13; Vol. 32 (1), pp. 200775. Date of Electronic Publication: 2024 Feb 13 (Print Publication: 2024).