The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

Autor: Léa J. Becker, Clémentine Fillinger, Robin Waegaert, Sarah H. Journée, Pierre Hener, Beyza Ayazgok, Muris Humo, Meltem Karatas, Maxime Thouaye, Mithil Gaikwad, Laetitia Degiorgis, Marie des Neiges Santin, Mary Mondino, Michel Barrot, El Chérif Ibrahim, Gustavo Turecki, Raoul Belzeaux, Pierre Veinante, Laura A. Harsan, Sylvain Hugel, Pierre-Eric Lutz, Ipek Yalcin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits and their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the neuronal pathway linking the basolateral amy

Externí odkaz: https://doaj.org/article/79edb28876214399bf2915cb6fdcd98c

Synthesis of New 3-Arylcoumarins Bearing

Autor: Ladan, Pourabdi, Tuba Tüylü, Küçükkılınç, Fatemeh, Khoshtale, Beyza, Ayazgök, Hamid, Nadri, Farid, Farokhi Alashti, Hamid, Forootanfar, Tayebeh, Akbari, Mohammad, Shafiei, Alireza, Foroumadi, Mohammad, Sharifzadeh, Mehdi, Shafiee Ardestani, M Saeed, Abaee, Loghman, Firoozpour, Mehdi, Khoobi, Mohammad M, Mojtahedi

Publikováno v: Frontiers in Chemistry

A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4be9c9135503e9902f855a2dd9f086b4
https://pubmed.ncbi.nlm.nih.gov/35127652

Neurotoxic effects of bisphenol A on SH-SY5Y neuroblastoma cells via nitric oxide

Autor: Beyza Ayazgök, Tuba Tüylü Küçükkılınç

Publikováno v: Journal of Research in Pharmacy. 23:354-359

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c3425ca5fd31f37dd9124b6c2e06c5
https://doi.org/10.12991/jrp.2019.143

Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors

Autor: Mehdi, Valipour, Issa, Davaji, Niusha, Abedi, Mahsa, Rajabi, Tuba Tüylü, Küçükkılınç, Beyza, Ayazgök, Hamid, Irannejad

Publikováno v: Iranian Journal of Pharmaceutical Research : IJPR

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53e14cf56222d6ad20582e844c005f3b
http://europepmc.org/articles/PMC6934981

Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway

Autor: Beyza Ayazgök, Tomi Rantamäki, Elisabeth Waltisperger, Muris Humo, Léa J. Becker, Ipek Yalcin

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2020, 100, pp.109898. ⟨10.1016/j.pnpbp.2020.109898⟩

International audience; Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socioeconomic burden and result in disability affecting millions indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca7d7a720b225bd79a79d814237e642
https://hal.archives-ouvertes.fr/hal-03001563/file/PNP_2020_accepted.pdf