Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists

Autor: Tellew, John E, Baska, Rose Ann F, Beyer, Sophie M, Carlson, Kenneth E, Cornelius, Lyndon A, Fadnis, Leena, Gu, Zhengxiang, Kunst, Bridgette L, Kowala, Mark C, Monshizadegan, Hossain, Murugesan, Natesan, Ryan, Carol S, Valentine, Maria T, Yang, Yifan, Macor, John E

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2003 13(6):1093-1096

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.

Autor: Huang A; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Jayaraman L; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Fura A; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Vite GD; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Trainor GL; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Gottardis MM; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Spires TE; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Spires VM; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Rizzo CA; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Obermeier MT; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Elzinga PA; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Todderud G; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Fan Y; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Newitt JA; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Beyer SM; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Zhu Y; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Warrack BM; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Goodenough AK; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Tebben AJ; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Doweyko AM; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Gold DL; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States., Balog A; Bristol-Myers Squibb Research and Development , Princeton, New Jersey 08543-4000, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Dec 02; Vol. 7 (1), pp. 40-5. Date of Electronic Publication: 2015 Dec 02 (Print Publication: 2016).

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Autor: Murugesan N; Discovery Chemistry and Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-5400, USA. natesan.murugesan@bms.com, Tellew JE, Gu Z, Kunst BL, Fadnis L, Cornelius LA, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Panchal B, Valentine MT, Chong S, Morrison RA, Carlson KE, Powell JR, Moreland S, Barrish JC, Kowala MC, Macor JE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Aug 29; Vol. 45 (18), pp. 3829-35.