Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.

Autor: Iliaki S; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Kreike M; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Ferreras Moreno N; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium; Center for Inflammation Research, Unit of Mouse Genetics and Inflammation, VIB, B-9052 Ghent, Belgium., De Meyer F; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Aidarova A; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Braun H; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Libert C; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium; Center for Inflammation Research, Unit of Mouse Genetics and Inflammation, VIB, B-9052 Ghent, Belgium., Afonina IS; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium., Beyaert R; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium. Electronic address: Rudi.Beyaert@irc.vib-ugent.be.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct; Vol. 228, pp. 116316. Date of Electronic Publication: 2024 May 24.

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.

Autor: O'Sullivan PA; The Francis Crick Institute, London NW1 1AT, U.K.; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Aidarova A; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Afonina IS; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Manils J; The Francis Crick Institute, London NW1 1AT, U.K.; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K.; Immunology Unit, Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona, Barcelona, Spain., Thurston TLM; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, U.K., Instrell R; The Francis Crick Institute, London NW1 1AT, U.K., Howell M; The Francis Crick Institute, London NW1 1AT, U.K., Boeing S; The Francis Crick Institute, London NW1 1AT, U.K., Ranawana S; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Herpels MB; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Chetian R; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Bassa M; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Flynn H; The Francis Crick Institute, London NW1 1AT, U.K., Frith D; The Francis Crick Institute, London NW1 1AT, U.K., Snijders AP; The Francis Crick Institute, London NW1 1AT, U.K., Howes A; National Heart and Lung Institute, Imperial College London, London W12 0NN, U.K., Beyaert R; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Bowcock AM; Department of Oncological Science, Dermatology, and Genetics and Genome Sciences, Icahn School of Medicine at Mount Sinai, New York 10029, U.S.A., Ley SC; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K.

Publikováno v: The Biochemical journal [Biochem J] 2024 Sep 18; Vol. 481 (18), pp. 1143-1171.

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice.

Autor: Skordos I; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Driege Y; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Haegman M; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Kreike M; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Staal J; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Demeyer A; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium., Beyaert R; Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Belgium.

Publikováno v: The FEBS journal [FEBS J] 2023 Apr; Vol. 290 (8), pp. 2032-2048. Date of Electronic Publication: 2022 Dec 19.

Laboratory mice with a wild microbiota generate strong allergic immune responses.

Autor: Ma J; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Urgard E; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.; Leo Foundation Skin Immunology Research Centre, Department of Immunology and Microbiology, University of Copenhagen, Denmark., Runge S; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Classon CH; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Mathä L; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Stark JM; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Cheng L; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Álvarez JA; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., von Zedtwitz S; Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany., Baleviciute A; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Martinez Hoyer S; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Li M; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Gernand AM; Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany., Osbelt L; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Bielecka AA; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Lesker TR; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Huang HJ; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, Vienna, Austria., Vrtala S; Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, Vienna, Austria., Boon L; JJP Biologics, Warsaw, Poland., Beyaert R; VIB Centre for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Adner M; Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Martinez Gonzalez I; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Strowig T; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.; Center for Individualized Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany., Du J; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Nylén S; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Rosshart SP; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany., Coquet JM; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.; Leo Foundation Skin Immunology Research Centre, Department of Immunology and Microbiology, University of Copenhagen, Denmark.

Publikováno v: Science immunology [Sci Immunol] 2023 Sep 29; Vol. 8 (87), pp. eadf7702. Date of Electronic Publication: 2023 Sep 29.

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids.

Autor: Borio A; Institute of Organic Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria., Holgado A; Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Ghent University, Technologiepark 71, B-9052 Ghent, Belgium., Passegger C; Division of Immunology and Pathophysiology, Medical University Graz, Heinrichstraße 31, 8010 Graz, Austria., Strobl H; Division of Immunology and Pathophysiology, Medical University Graz, Heinrichstraße 31, 8010 Graz, Austria., Beyaert R; Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Ghent University, Technologiepark 71, B-9052 Ghent, Belgium., Heine H; Research Group Innate Immunity, Priority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Parkallee 22, 23845 Borstel, Germany., Zamyatina A; Institute of Organic Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 08; Vol. 28 (16). Date of Electronic Publication: 2023 Aug 08.