Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bey-Dih Chang"'
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1534
Cellular senescence is a unique process of normal physiology, from embryonic development to aging, also known for its association with a broad range of pathological conditions. Therefore a reliable model of cellular senescence remains an indispensabl
Publikováno v:
Methods in Molecular Biology ISBN: 9781493966684
Cellular senescence is a unique process of normal physiology, from embryonic development to aging, also known for its association with a broad range of pathological conditions. Therefore a reliable model of cellular senescence remains an indispensabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eaa60d4603ac13c2bcf33ce02356dc9
https://doi.org/10.1007/978-1-4939-6670-7_3
https://doi.org/10.1007/978-1-4939-6670-7_3
Autor:
Michael J. Dunn, Caroline A. Currid, Igor B. Roninson, William M. Gallagher, Stephen R. Pennington, Nathan Harris, Kenneth A. Dawson, Bey-Dih Chang, Caroline Gebus, Darran P. O'Connor
Publikováno v:
PROTEOMICS. 6:3739-3753
The p21Waf1/Cip1/Sdi1 cyclin-dependent kinase inhibitor is a key regulator of cell cycle progression and has also been observed to influence the expression of genes associated with several age-related disorders. Previous work has shown that expressio
Autor:
Mari E. Swift, Mark W. Lingen, Jonathan L. Curry, Brian J. Nickoloff, Patricia Bacon, Mei Shen, Bey-Dih Chang, Barbara Bodner, Igor B. Roninson
Publikováno v:
Cancer Research. 64:2956-2961
Cell senescence is a physiological program of terminal growth arrest, which is believed to play an important role in cancer prevention. Senescent cells secrete multiple growth-regulatory proteins, some of which can affect tumor growth, survival, inva
Autor:
Stacey Fellars, Thomas Primiano, Sergey A. Axenovich, Anil Maliyekkel, Holzmayer Tatyana, Igor B. Roninson, Mirza S. Baig, Bey-Dih Chang, Justin Sadhu
Publikováno v:
Cancer Cell. 4:41-53
To identify human genes required for tumor cell growth, transcriptome-scale selection was used to isolate genetic suppressor elements (GSEs) inhibiting breast carcinoma cell growth. Growth-inhibitory GSEs (cDNA fragments that counteract their cognate
Publikováno v:
Cell Cycle. 1:55-62
Induction of p21 (WAF1/CIP1/SDI1), a physiological mediator of cell cycle arrest, inhibits multiple genes involved in cell division. We have investigated the determinants of p21- mediated inhibition of two of these genes, polo-like kinase 1 (PLK1) an
Autor:
Eugenia V. Broude, Keiko Watanabe, Igor B. Roninson, Jing Fang, Bey-Dih Chang, Jason C. Poole, Tatiana V. Kalinichenko
Publikováno v:
Proceedings of the National Academy of Sciences. 97:4291-4296
Induction of cyclin-dependent kinase inhibitor p21Waf1/Cip1/Sdi1triggers cell growth arrest associated with senescence and damage response. Overexpression of p21 from an inducible promoter in a human cell line induces growth arrest and phenotypic fea
Autor:
Brigitte Schott, Bey-Dih Chang, Yongzhi Xuan, Jing Fang, Eugenia V. Broude, Igor B. Roninson, Hongming Zhu
Publikováno v:
Oncogene. 18:4808-4818
Exposure of human tumor cell lines to moderate doses of anticancer agents induces terminal proliferation arrest accompanied by morphologic and enzymatic changes that resemble senescence of normal cells. We have investigated the role of p53 and p21waf
Autor:
Gregory Hurteau, Mengqian Chen, Donald C. Porter, Jun Shi, Mark P. Wentland, Gary P. Schools, Athanasios G. Papavassiliou, Rebecca Rokow-Kittell, Deborah K. West, Hippokratis Kiaris, Eugenia V. Broude, Igor B. Roninson, Balazs Gyorffy, Chang-uk Lim, Phil S. Baran, Anatoliy T. Puzyrev, Serena Altilia, Elena Farmaki, Bey-Dih Chang, S Kalurupalle, Lawrence T. Friedhoff
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(34)
Conventional chemotherapy not only kills tumor cells but also changes gene expression in treatment-damaged tissues, inducing production of multiple tumor-supporting secreted factors. This secretory phenotype was found here to be mediated in part by a
Autor:
Eugenia V. Broude, Mikhail V. Blagosklonny, Bey-Dih Chang, Brian Davis, S Kalurupalle, Igor B. Roninson, Swift Me, Claire Vivo
Publikováno v:
Oncogene. 26(48)
Damage-induced G1 checkpoint in mammalian cells involves upregulation of p53, which activates transcription of p21(Waf1) (CDKN1A). Inhibition of cyclin-dependent kinase (CDK)2 and CDK4/6 by p21 leads to dephosphorylation and activation of Rb. We now