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NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Autor: Ryan, Eilise, Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R, Zhang, Ailiang, Howden, Andrew J M, Sanchez Garcia, Manuel Alejandro, Bewley, Martin A., Cole, Joby, McHugh, Brian, Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, von Kriegsheim, Alexander, Sanchez, Yolanda, Rumsey, William, Callahan, James F, Cooper, George, Parkinson, Nicholas, Baillie, J Kenneth, Cantrell, Doreen, McCafferty, John, Choudhury, Gourab, Singh, David, Dockrell, David H, Whyte, Moira K B, Walmsley, Sarah R

Publikováno v: Ryan, E, Sadiku, P, Coelho, P, Watts, E R, Zhang, A, Howden, A J M, Sanchez Garcia, M A, Bewley, M A, Cole, J, McHugh, B, Vermaelen, W, Ghesquiere, B, Carmeliet, P, Rodriguez Blanco, G, von Kriegsheim, A, Sanchez, Y, Rumsey, W, Callahan, J F, Cooper, G, Parkinson, N, Baillie, J K, Cantrell, D, McCafferty, J, Choudhury, G, Singh, D, Dockrell, D H, Whyte, M K B & Walmsley, S R 2023, ' NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0482OC

Rationale: COPD (Chronic Obstructive Pulmonary Disease) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::fe09787fc19ea59a2ff88a8d7a9dc9ab
https://www.pure.ed.ac.uk/ws/files/323890313/Complete_AJRCCM_MS.pdf

HIV gp120 in Lungs of ART-treated individuals impairs alveolar macrophage responses to pneumococci

Autor: Collini, Paul J., Bewley, Martin A., Mohasin, Mohamed, Marriott, Helen M., Miller, Robert F., Geretti, Anna-Maria, Beloukas, Apostolos, Papadimitropoulos, Athanasios, Read, Robert C., Noursadeghi, Mahdad, Dockrell, David H.

Rationale People living with HIV (PLWH) are at significantly increased risk of invasive pneumococcal disease, despite long-term antiretroviral therapy (ART). The mechanism explaining this observation remains undefined. Objectives We hypothesized apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______348::6d7017ecf6b0957995ab4842cf165465
https://eprints.soton.ac.uk/422255/

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis

Autor: Salamaga, Bartłomiej, Prajsnar, Tomasz K., Jareño-Martinez, Ana, Willemse, Joost, Bewley, Martin A., Chau, Françoise, Ben Belkacem, Tassadit, Meijer, Annemarie H., Dockrell, David H., Renshaw, Stephen A., Mesnage, Stéphane

Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006526 (2017)
PLoS Pathogens
Salamaga, B, Prajsnar, T K, Jareño-Martinez, A, Willemse, J, Bewley, M A, Chau, F, Ben Belkacem, T, Meijer, A H, Dockrell, D H, Renshaw, S A & Mesnage, S 2017, ' Bacterial size matters : Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis ', PLoS Pathogens, vol. 13, no. 7, pp. e1006526 . https://doi.org/10.1371/journal.ppat.1006526

Enterococcus faecalis is an opportunistic pathogen frequently isolated in clinical settings. This organism is intrinsically resistant to several clinically relevant antibiotics and can transfer resistance to other pathogens. Although E. faecalis has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cb819b934d991d455e7eb7788a2c9b7d
https://doaj.org/article/1a742257308e47bd9748ea7d865fdd1d

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