HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci

Autor: Collini, P.J., Bewley, M.A., Mohasin, M., Marriott, H.M., Miller, R.F., Geretti, A.M., Beloukas, A., Papadimitropoulos, A., Read, R.C., Noursadeghi, M., Dockrell, D.

Rationale People living with HIV (PLWH) are at significantly increased risk of invasive pneumococcal disease, despite long-term antiretroviral therapy (ART). The mechanism explaining this observation remains undefined. Objectives We hypothesized apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9a6e3d04a9821ea09df50a2bc93e5536
https://eprints.whiterose.ac.uk/126027/1/Collini_gp120Spn_Blue-201708-1755OC_Manuscript_R1_Clean.pdf

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Autor: Bewley, M.A., Belchamber, K.B., Chana, K.K., Budd, R.C., Donaldson, G., Wedzicha, J.A., Brightling, C.E., Kilty, I., Donnelly, L.E., Barnes, P.J., Singh, D., Whyte, M.K., Dockrell, D.H.

Publikováno v: Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139
PLoS ONE
Bewley, M A, Belchamber, K B R, Chana, K K, Budd, R C, Donaldson, G, Wedzicha, J A, Brightling, C E, Kilty, I, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B, Dockrell, D H & COPDMAP 2016, ' Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD ', PLoS ONE, vol. 11, no. 9, pp. e0163139 . https://doi.org/10.1371/journal.pone.0163139

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f5e1cdf1f91ed01a502d9fb84d3a19f
https://www.pure.ed.ac.uk/ws/files/28576749/Whyte_M_Differential_effects....pdf

Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages

Autor: Jubrail, J., Morris, P., Bewley, M.A., Stoneham, S., Johnston, S.A., Foster, S.J., Peden, A.A., Read, R.C., Marriott, H.M., Dockrell, D.H.

Macrophages are critical effectors of the early innate response to bacteria in tissues. Phagocytosis and killing of bacteria are interrelated functions essential for bacterial clearance but the rate-limiting step when macrophages are challenged with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6864c0f768f5ca01fbbfd836d8399487

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection

Autor: Daigneault, M., De Silva, T.I., Bewley, M.A., Preston, J.A., Marriott, H.M., Mitchell, A.M., Mitchell, T.J., Read, R.C., Whyte, M.K.B., Dockrell, D.H.

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incomplete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::94d4303ffe4742c682ac059a346121f7

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