Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Bevyn Jarrott"'
Autor:
Richard J. Head, Eugenie R. Lumbers, Bevyn Jarrott, Felix Tretter, Gary Smith, Kirsty G. Pringle, Saiful Islam, Jennifer H. Martin
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract Why a systems analysis view of this pandemic? The current pandemic has inflicted almost unimaginable grief, sorrow, loss, and terror at a global scale. One of the great ironies with the COVID‐19 pandemic, particularly early on, is counter
Externí odkaz:
https://doaj.org/article/132b3f35d5f34085b479372eba541eac
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract Infection of humans with SARS‐CoV‐2 virus causes a disease known colloquially as “COVID‐19” with symptoms ranging from asymptomatic to severe pneumonia. Initial pathology is due to the virus binding to the ACE‐2 protein on endoth
Externí odkaz:
https://doaj.org/article/114570a35c2f498f8a50f59daeaf5591
Autor:
Eugenie R. Lumbers, Richard Head, Gary R. Smith, Sarah J. Delforce, Bevyn Jarrott, Jennifer H.Martin, Kirsty G. Pringle
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract SARS‐CoV‐2 interacting with its receptor, angiotensin‐converting enzyme 2 (ACE2), turns the host response to viral infection into a dysregulated uncontrolled inflammatory response. This is because ACE2 limits the production of the pept
Externí odkaz:
https://doaj.org/article/da485de05a3d4caea7d795e8b296e828
Publikováno v:
MethodsX, Vol 1, Iss C, Pp 212-216 (2014)
Research into the galanin-3 (GAL3) receptor has many challenges, including the lack of commercially available selective ligands. While the identification of non-peptidergic GAL3 receptor-selective antagonists, 1-phenyl-3-[3-(trifluoromethyl)phenyl]im
Externí odkaz:
https://doaj.org/article/019f59deb60347c5be9b11d6d8ed10dd
Publikováno v:
Journal of Neurochemistry. 155:345-347
This is an Obituary for Leslie Iversen (1937-2020). Les Iversen was an internationally renowned neuroscientist and pharmacologist, a substantial contributor to university life, learned societies, the pharmaceutical industry and society at large. He d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7038eb729125217508e4e918cf9ecd7c
https://doi.org/10.1111/jnc.15163
https://doi.org/10.1111/jnc.15163
Publikováno v:
ChemMedChem. 14:570-582
We previously reported that a lipophilic N-(4'-hydroxy-3',5'-di-tert-butylbenzyl) derivative (1) of the voltage-gated sodium channel blocker mexiletine, was a more potent sodium channel blocker in vitro and in vivo. We demonstrate that replacing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e24850d49d532b1084d094d55915a68
https://doi.org/10.1002/cmdc.201800781
https://doi.org/10.1002/cmdc.201800781
Autor:
Bevyn Jarrott
Publikováno v:
Pharmacological Research. 116:29-31
Tacrine was initially synthesised in 1945 as part of a project seeking antibacterial drugs to treat infected wounds in soldiers. However, it was inactive in vitro against common strains of bacteria. Serendipitously, it was injected in vivo into dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485eeef8833478e4d2349df1b933bfd3
https://doi.org/10.1016/j.phrs.2016.12.033
https://doi.org/10.1016/j.phrs.2016.12.033
Autor:
Bevyn Jarrott, Spencer J. Williams
Publikováno v:
Neurochemical Research. 41:523-533
It is now recognised that the brain and the peripheral immune system have bidirectional communication in both health and neuronal diseases. Brain inflammation results after both acute injury and also with the appearance of mutated proteins or endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae8636f526a5f1f6496ac0d3bebcfca
https://doi.org/10.1007/s11064-015-1661-7
https://doi.org/10.1007/s11064-015-1661-7
Autor:
Christina Y. R. Tan, James Ziogas, Alyson A. Miller, Paul J. White, Grant R Drummond, Christine E. Wright, Bevyn Jarrott, Kamani Rupika Subasinghe, Bich Anh Chau, W. Roy Jackson
Publikováno v:
MedChemComm. 6:634-639
Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c465865d81316baa97769708562f65b
https://doi.org/10.1039/c4md00459k
https://doi.org/10.1039/c4md00459k
Autor:
Mohammad Allahtavakoli, Bevyn Jarrott
Publikováno v:
Brain Research Bulletin. 85:219-224
Sigma receptor agonists have been found to provide potent neuroprotection in rats and mice. This neuroprotection is thought to be mediated through anti-excitotoxic mechanisms. Neuroprotective and immune modulatory effects of sigma ligands have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c10409a3e7ab75df469e76fc4f4e34
https://doi.org/10.1016/j.brainresbull.2011.03.019
https://doi.org/10.1016/j.brainresbull.2011.03.019