Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Bevra H. Hahn"'
Autor:
Brian J. Skaggs, Jennifer Grossman, Lori Sahakian, Lucas Perry, John FitzGerald, Christina Charles‐Schoeman, Alan Gorn, Mihaela Taylor, John Moriarty, Nagesh Ragavendra, Michael Weisman, Daniel J. Wallace, Bevra H. Hahn, Maureen McMahon
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 4, Pp 209-220 (2021)
Objective The increase in cardiovascular events (CVEs) in systemic lupus erythematosus (SLE) is not fully explained by traditional risk factors. We previously identified four biomarkers (proinflammatory high‐density lipoprotein, leptin, soluble TNF
Externí odkaz:
https://doaj.org/article/02966150902547ddb3354a6c17ef0378
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recently microRNAs (miRNAs) have been recognized as powerful regulators of many genes and pathways involved in the pathogenesis of inflammatory diseases including Systemic Lupus Erythematosus (SLE). SLE is an autoimmune disease characterized by produ
Externí odkaz:
https://doaj.org/article/f1d1d8275ecf43f1bc5e44562abcc0e7
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with widespread inflammation, immune dysregulation, and is associated with the generation of destructive anti-DNA autoantibodies. We have shown previously the immune modulatory proper
Externí odkaz:
https://doaj.org/article/d6ae1a7560b5498c95a04b8e4056203c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recent evidence suggests the existence of a nexus between inflammatory pathways and the female sex hormone 17β-estradiol, resulting in increased interferon-stimulated genes (ISGs), autoantibodies, and dysregulation of immune cells in SLE. However, t
Externí odkaz:
https://doaj.org/article/c95b5f7cf7ac4c7daacfceca8fafd6ec
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The regulation of autoimmunity and the molecular mechanisms by which different immune cells, including T cells, polymorphonuclear leukocytes (PMN-granulocytes), and B cells suppress autoimmune diseases is complex. We have shown previously that BWF1 l
Externí odkaz:
https://doaj.org/article/dfb1f47e756b4af28d421ae41e6b796c
Autor:
Jim C Oates, Qing Sun, Joel M Guthridge, Judith A James, Lei Wang, Diane L Kamen, Fang Wang, Miaojia Zhang, Gary S Gilkeson, Deborah K McCurdy, Lingxiao Xu, Wenfeng Tan, Jian Zhao, Ting Liu, Bevra H Hahn, Betty P Tsao, R Hal Scofield, Yun Deng, Prithvi Raj, Edward K Wakeland, Linyu Geng, Xue Xu, Yunjuan Wu, Jingfeng Zhu, Alexander Awgulewitsch
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/29d520723cca4e048732eacb99f2b0c0
Autor:
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L Kamen, Jim C Oates, Prithvi Raj, Edward K Wakeland, R Hal Scofield, Joel M Guthridge, Judith A James, Bevra H Hahn, Deborah K McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S Gilkeson, Betty P Tsao
Publikováno v:
Annals of the Rheumatic Diseases. 81:1712-1721
ObjectivesFamilies that contain multiple siblings affected with childhood onset of systemic lupus erythematosus (SLE) likely have strong genetic predispositions. We performed whole exome sequencing (WES) to identify familial rare risk variants and to
Autor:
Ronald F van Vollenhoven, Kenneth C Kalunian, Thomas Dörner, Bevra H Hahn, Yoshiya Tanaka, Robert M Gordon, Cathye Shu, Kaiyin Fei, Sheng Gao, Loqmane Seridi, Patrick Gallagher, Kim Hung Lo, Pamela Berry, Qing C Zuraw
Publikováno v:
Annals of the rheumatic diseases, vol 81, iss 11
van Vollenhoven, R F, Kalunian, K C, Dörner, T, Hahn, B H, Tanaka, Y, Gordon, R M, Shu, C, Fei, K, Gao, S, Seridi, L, Gallagher, P, Lo, K H, Berry, P & Zuraw, Q C 2022, ' Phase 3, multicentre, randomised, placebo-controlled study evaluating the efficacy and safety of ustekinumab in patients with systemic lupus erythematosus ', Annals of the Rheumatic Diseases, vol. 81, no. 11, 222858, pp. 1556-1563 . https://doi.org/10.1136/ard-2022-222858
Annals of the Rheumatic Diseases, 81(11):222858, 1556-1563. BMJ Publishing Group
Annals of the rheumatic diseases, 81(11):222858, 1556-1563. BMJ Publishing Group
van Vollenhoven, R F, Kalunian, K C, Dörner, T, Hahn, B H, Tanaka, Y, Gordon, R M, Shu, C, Fei, K, Gao, S, Seridi, L, Gallagher, P, Lo, K H, Berry, P & Zuraw, Q C 2022, ' Phase 3, multicentre, randomised, placebo-controlled study evaluating the efficacy and safety of ustekinumab in patients with systemic lupus erythematosus ', Annals of the Rheumatic Diseases, vol. 81, no. 11, 222858, pp. 1556-1563 . https://doi.org/10.1136/ard-2022-222858
Annals of the Rheumatic Diseases, 81(11):222858, 1556-1563. BMJ Publishing Group
Annals of the rheumatic diseases, 81(11):222858, 1556-1563. BMJ Publishing Group
ObjectiveEvaluate the efficacy and safety of ustekinumab, an anti-interleukin-12/23 p40 antibody, in a phase 3, randomised, placebo-controlled study of patients with active systemic lupus erythematosus (SLE) despite receiving standard-of-care.Methods
Autor:
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L Kamen, Jim C Oates, Prithvi Raj, Edward K Wakeland, R Hal Scofield, Joel M Guthridge, Judith A James, Bevra H Hahn, Deborah K McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S Gilkeson, Betty P Tsao
Publikováno v:
Molecular Biology of Lupus.
Publikováno v:
Rheumatology and Immunology Research. 2:147-156
T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these cells have